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Transcriptional changes in experimentally-induced basal to squamous cell carcinoma transition (BST) upon treatment with small molecule inhibitors [ASZ_RNAseq_inhibitor]

ABSTRACT: Transcriptional changes in experimentally-induced basal to squamous cell carcinoma transition (BST) upon treatment with small molecule inhibitors [ASZ_RNAseq_inhibitor]

PROVIDER: PRJNA701355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13684264_1.fastq.gz	Fastqsanger.gz
	SRR13684264_2.fastq.gz	Fastqsanger.gz
	SRR13684265_1.fastq.gz	Fastqsanger.gz
	SRR13684265_2.fastq.gz	Fastqsanger.gz
	SRR13684266_1.fastq.gz	Fastqsanger.gz

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Project description:Basal cell carcinoma may undergo BST spontaneously or upon Hedgehog targeting therapy. We identified that modulation of Ras/MAPK or TGFb signaling drive BST. Here, we induce Ras/MAPK and/or abrogate TGFb signaling to induce BST. Alternatively we drive c-FOS to induce BST. In these various experimentally-induced model of BST, we analyze chromatin accessibility profiles upon Ras/MAPK activation and/or TGFb signaling abrogation. We also analyze chromatin accessibility profiles upon c-FOS activation.

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