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APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression

ABSTRACT: APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression

PROVIDER: PRJNA701898 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13696474.fastq.gz	Fastqsanger.gz
	SRR13696475.fastq.gz	Fastqsanger.gz
	SRR13696476.fastq.gz	Fastqsanger.gz
	SRR13696477.fastq.gz	Fastqsanger.gz
	SRR13696478.fastq.gz	Fastqsanger.gz

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APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression [RNA-Seq]

Project description:APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression [RNA-Seq]

| PRJNA701559 | ENA

APE1 controls DICER1 expression through functional regulation of miRNA33a and miRNA130b: a novel hypothesis for NSCLC cancer progression [NanoString]

Project description:Lung cancer is the leading cause of cancer death worldwide. The lack of specific and sensitive methods for early diagnosis as well as inadequate targeted therapies contribute to poor outcomes. A growing body of evidences suggests different roles of microRNAs including development and progression of lung cancer. The overexpression of the DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) is an important cause of poor chemotherapeutic and its expression is able to predict the progression-free and overall survival in patients receiving platinum-containing chemotherapy. Recently, we have demonstrated APE1 involvement in miRNA biogenesis related to cancer progression. In this article, we report the identification of miRNAs that are modulated in lung cancer cells upon APE1 silencing. We defined a miRNA signature consisting of the 13 miRNAs, which strongly correlates with APE1 expression in lung cancer: miR-1246, miR-4488, miR-24, miR-183, miR-660, miR-130b, miR-543, miR-200c, miR-376c, miR-218, miR-146a, miR-92b and miR-33a. Gene ontology annotation and pathway analysis of the miRNA signature revealed its biological significance in cancer proliferation and survival. Among the miRNAs downregulated by APE1 is miRNA-33a-5p which targets Dicer, a major miRNA biogenesis gene whose expression is found to be downregulated in several tumours. We here validated Dicer as a direct functional target of miR-33a and profiled miR-33a, DICER and APE1 expression in clinical samples. Our findings suggest that APE1 may promote lung cancer progression through modulation of Dicer expression via miR-33a regulation. Our findings reveal new mechanistic insight into how APE1 functions in tumor biology.

2022-08-03 | GSE166749 | GEO

APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression [RNA-Seq]

Project description:The overexpression of the DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) is an important cause of poor outcome and its expression is able to predict the progression-free and overall survival in patients receiving platinum-containing chemotherapy. Recently, we have demonstrated APE1 involvement in miRNA biogenesis related to cancer progression.

2022-08-03 | GSE166664 | GEO

APE1 controls DICER1 expression through functional regulation of miRNA33a and miRNA130b: a novel hypothesis for NSCLC cancer progression [NanoString]

Project description:APE1 controls DICER1 expression through functional regulation of miRNA33a and miRNA130b: a novel hypothesis for NSCLC cancer progression [NanoString]

| PRJNA701901 | ENA

Dicer knockout NSCLC RNAseq and miRseq

Project description:Dicer knockout NSCLC mRNAseq profiles the transcriptome, Dicer knockout NSCLC miRseq profiles the miRnome

2014-04-25 | GSE57043 | GEO

APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-03 | GSE166750 | GEO

Dicer knockout NSCLC RNAseq and miRseq

Project description:Dicer knockout NSCLC mRNAseq profiles the transcriptome, Dicer knockout NSCLC miRseq profiles the miRnome DicerHet and DicerKO NSCLC, 2 biological reps each genotype for mRNAseq, 1 biological rep each for miRseq

2014-04-25 | E-GEOD-57043 | biostudies-arrayexpress

Gene expression influenced by human APE1 and mouse Ape1 in a mouse embryonic fibroblast line.

Project description:APE1 (AP-endonuclease 1) is an essential DNA repair protein but also it functions as a gene regulatory protein. A unique mouse embyonic fibroblast with almost undetectable levels of APE1 was isolated. Three isogenic derivatives of this cell line that contain either of the control vector, the human APE1 cDNA, and mouse Ape1 cDNA were analyzed for their global gene expression using Affymetrix mouse ST 2.0 chip set.

2016-01-31 | GSE55765 | GEO

Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) activates Notch signaling through Jagged1 expression and promotes colon cancer progression

Project description:To investigate the possible role of Ape1/Ref-1 in tumorigenicity of colon cancer and explored the oncogenic mechanism of Ape1/Ref-1 in colon cancer cells. Control and Ref-1 overexpressing SW480cells, control and Ref-1-deficient SW480 cells. Duplicate

2013-04-17 | E-GEOD-45912 | biostudies-arrayexpress

Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) activates Notch signaling through Jagged1 expression and promotes colon cancer progression

Project description:To investigate the possible role of Ape1/Ref-1 in tumorigenicity of colon cancer and explored the oncogenic mechanism of Ape1/Ref-1 in colon cancer cells.

2013-04-17 | GSE45912 | GEO

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