Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq, sorted macrophages)

ABSTRACT: A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq, sorted macrophages)

PROVIDER: PRJNA703095 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13748983.fastq.gz	Fastqsanger.gz
	SRR13748984.fastq.gz	Fastqsanger.gz
	SRR13748985.fastq.gz	Fastqsanger.gz
	SRR13748986.fastq.gz	Fastqsanger.gz
	SRR13748987.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

A genetic program boosts mitochondrial function to power macrophage tissue invasion

Project description:A genetic program boosts mitochondrial function to power macrophage tissue invasion

| PRJNA703050 | ENA

A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq, sorted macrophages)

Project description:Metabolic adaptation to changing demands underlies homeostasis. During inflammation or metastasis, cells leading migration into challenging environments require an energy boost, however what controls this capacity is unknown. We identify a previously unstudied nuclear protein, Atossa, as changing metabolism in Drosophila melanogaster immune cells to promote tissue invasion. Atossa's vertebrate orthologs, FAM214A-B can fully substitute for Atossa, indicating functional conservation from flies to mammals. Atossa increases mRNA levels of Porthos, an unstudied RNA helicase and two metabolic enzymes, LKR/SDH and GR/HPR. Porthos increases translation of a gene subset, including those affecting mitochondrial functions, the electron transport chain, and metabolism. Respiration measurements and metabolomics indicate that Atossa and Porthos power up mitochondrial oxidative phosphorylation to produce sufficient energy for pioneer macrophages to forge a path into tissues. As increasing oxidative phosphorylation enables many crucial physiological responses, this unique genetic program may modulate a wide range of cellular behaviors beyond migration.

2021-12-15 | GSE167132 | GEO

A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq/Polysome-seq, S2 cells)

Project description:A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq/Polysome-seq, S2 cells)

| PRJNA703094 | ENA

A genetic program boosts mitochondrial function to power macrophage tissue invasion (RNA-seq/Polysome-seq, S2 cells)

2021-12-15 | GSE167133 | GEO

A genetic program boosts mitochondrial function to power macrophage tissue invasion

Project description:This SuperSeries is composed of the SubSeries listed below. This includes RNA seq data on macrophages FACs sorted from wt or atos- (aka CG9005)- embryos (4 replicates); RNA seq of total RNA (input) from wt S2 cells or those treated with RNAi against porthos; andRNA seq of RNA obtained from the polysome fraction of wt S2 cells or those treated with RNAi against porthos. (3 replicates for each)

2021-12-15 | GSE167134 | GEO

power plant metagenome

Project description:power plant metagenome Raw sequence reads

| PRJNA407460 | ENA

Extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT) boosts IFNγ-induced macrophage polarization

Project description:Extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT) boosts IFNγ-induced macrophage polarization

| PRJNA781578 | ENA

A conserved atypical MFS family member orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion

Project description:Aberrant display of the truncated core1 O-glycan T-antigen is a common feature of human cancer cells that correlates with metastasis. Here we show that T-antigen in Drosophila melanogaster macrophages is involved in their developmentally programmed tissue invasion. Higher macrophage T-antigen levels require an atypical major facilitator superfamily (MFS) member that we named Minerva which enables macrophage dissemination and invasion. We characterize for the first time the T and Tn glycoform O-glycoproteome of the Drosophila melanogaster embryo, and determine that Minerva increases the presence of T-antigen on protein pathways previously linked to cancer, most strongly on the protein sulfhydryl oxidase Qsox1 which we show is required for macrophage invasion. Minerva’s vertebrate ortholog, MFSD1, rescues the minerva mutant’s migration and T-antigen glycosylation defects. We thus identify a key conserved regulator that orchestrates O-glycosylation on a protein subset to activate a program governing migration steps important for both development and cancer metastasis

2019-04-01 | PXD011045 | Pride

Claudin 7 suppresses invasion and metastasis through repression of a smooth muscle actin program

Project description:Claudin 7 suppresses invasion and metastasis through repression of a smooth muscle actin program

| PRJNA1142033 | ENA

Cheatgrass Invasion

Project description:Cheatgrass Invasion Raw sequence reads

| PRJNA771000 | ENA