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Cytomegalovirus subverts macrophage identity [LysMcreZeb1flox_vs_LysMcreZeb1wt]

ABSTRACT: Cytomegalovirus subverts macrophage identity [LysMcreZeb1flox_vs_LysMcreZeb1wt]

PROVIDER: PRJNA703928 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR13762470_1.fastq.gz	Fastqsanger.gz
	SRR13762470_2.fastq.gz	Fastqsanger.gz
	SRR13762471_1.fastq.gz	Fastqsanger.gz
	SRR13762471_2.fastq.gz	Fastqsanger.gz
	SRR13762472_1.fastq.gz	Fastqsanger.gz

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Project description:Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARÎ³ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. Development of the fetal monocyte derived AM precursor was largely abrogated in CD11c-Cre/Ppargfl/fl mice. To reveal the underlying changes in gene expression, we performed microarray analysis of sorted WT and KO AM and pre-AM from 3 different timepoints. Part1: d2 and d11 sorts & array pre-AM FACS-sorted from lungs of d2 and mature AM from d11 PPARgfl/fl (WT) and CD11c-cre/PPARgfl/fl (KO) mice and subsequently processed for RNA extraction and hybridization on Affymetrix microarrays. 2 biological replicates per group, each composed of pooled cells from 2 individual mice

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