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RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

ABSTRACT: RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

PROVIDER: PRJNA707561 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR13895066.fastq.gz	Fastqsanger.gz
	SRR13895067.fastq.gz	Fastqsanger.gz
	SRR13895068.fastq.gz	Fastqsanger.gz
	SRR13895069.fastq.gz	Fastqsanger.gz
	SRR13895070.fastq.gz	Fastqsanger.gz

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scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. Tumors generated from this mouse model were dissociated and a 10X genomics library preparation was performed. The barcoded library was then deep sequenced.

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RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

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Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a TAZ-CAMTA1 fusion in greater than 90% of cases and loss of CDKN2A in human EHE tumors is associated with late stage disease. Murine EHE tumors were created by conditionally expressing TAZ-CAMTA1 and conditionally knocking out Cdkn2a within vascular endothelium. Resultant tumors were used for single cell RNA sequencing and compared against age matched wild type mice tissue.

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