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Effects of dietary folic acid levles on colitis-associated tumorigenesis.

ABSTRACT: Effects of dietary folic acid levles on colitis-associated tumorigenesis.

PROVIDER: PRJNA708207 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13911600_1.fastq.gz	Fastqsanger.gz
	SRR13911600_2.fastq.gz	Fastqsanger.gz
	SRR13911601_1.fastq.gz	Fastqsanger.gz
	SRR13911601_2.fastq.gz	Fastqsanger.gz
	SRR13911602_1.fastq.gz	Fastqsanger.gz

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Effects of dietary folic acid levles on colitis-associated tumorigenesis.

Project description:Folic acid supplementation (8 mg/kg diet) promotes colon tumor formation in mice with established colitis induced by carcinogen azoxymethane (AOM) and dextran sulfate sodium sulfate (DSS). This induction of colon tumors was associated with hypomethylation of DNA cased by folic acid supplementation.

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Project description:Folic acid is present in pre-natal vitamins, fortified cereal grains and multi-vitamin supplements. High intake of folic acid through these sources has resulted in populations with increased levels of serum folate and unmetabolized folic acid. Although the benefits of folic acid in the prevention of neural tube defects are undeniable, the impact of long-term consumption of folic acid on the prostate is not fully understood. In this study, we used a rodent model to test whether dietary folic acid (FA) supplementation changes prostate homeostasis and response to androgen deprivation. Although intact prostate weights do not differ between diet groups, we made the surprising observation that dietary folic acid supplementation confers partial resistance to castration-mediated prostate involution. More specifically, male mice that were fed a folic acid supplemented diet and then castrated had greater prostate wet weights, greater prostatic luminal epithelial cell heights, and more abundant RNAs encoding prostate secretory proteins compared to mice that were fed a control diet and castrated. We used RNA-seq to identify signaling pathways enriched in the castrated prostates from folic acid supplemented diet fed mice compared to control mice. We observed differential expression of genes involved in several metabolic pathways in the FA supplemented mice. Together, our results show that dietary FA supplementation can impact metabolism in the prostate and attenuate the prostate’s response to androgen deprivation. This has important implications for androgen deprivation therapies used in the treatment of prostate disease, as consumption of high levels of folic acid could reduce the efficacy of these treatments.

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