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Treatment of Pulmonary Hypertension and Sickle Cell Disease With Sildenafil Therapy (Walk-PHaSST)

ABSTRACT: Treatment of Pulmonary Hypertension and Sickle Cell Disease With Sildenafil Therapy (Walk-PHaSST)

PROVIDER: PRJNA715522 | ENA |

REPOSITORIES: ENA

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Treatment of Pulmonary Hypertension and Sickle Cell Disease With Sildenafil Therapy (Walk-PHaSST)

Project description:Treatment of Pulmonary Hypertension and Sickle Cell Disease With Sildenafil Therapy (Walk-PHaSST)

| PRJNA715521 | ENA

NHLBI TOPMed: Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST)

Project description:NHLBI TOPMed: Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST)

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NHLBI TOPMed: Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST)

Project description:NHLBI TOPMed: Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST)

| PRJNA423125 | ENA

A Validated Gene Signature from Peripheral Blood Mononuclear Cells in Pulmonary Hypertension Associated with Sickle Cell Disease

Project description:Pulmonary hypertension (PH) is a serious complication of sickle cell disease (SCD) associated with increased mortality. Gene expression profiles of peripheral blood mononuclear cells (PBMC) have been studied in pulmonary arterial hypertension and in SCD. We hypothesized that a PBMC-derived gene signature in SCD patients may be utilized as a PH biomarker. Twenty-seven patients with homozygous SCD underwent transthoracic echocardiography and PBMC isolation. PH was defined as estimated right ventricular systolic pressure (RVSP)>30 mmHg with a peak tricuspid regurgitation velocity (TRV)>2.5m/s. Genome-wide gene expression profiles were correlated against PH severity using RVSP and TRV as surrogates, which yielded 631 potentially dysregulated transcripts. Total RNA was isolated from PBMCs using standard molecular biology protocols without DNA contamination or RNA degradation. Sample processing (e.g., cDNA generation, fragmentation, end labeling, hybridization to Affymetrix GeneChip Human Exon 1.0 ST arrays) was performed per manufacturer’s instructions. A total of 27 African descent American patients with sickle cell disease were included in the microarray analysis.

2012-06-06 | E-GEOD-38528 | biostudies-arrayexpress

A Validated Gene Signature from Peripheral Blood Mononuclear Cells in Pulmonary Hypertension Associated with Sickle Cell Disease

2012-06-07 | GSE38528 | GEO

Hypoxic pulmonary hypertension study

Project description:These microarray studies were performed using whole lungs of BALB/C mice during development of hypoxia-induced pulmonary hypertension (days 1-21) and resolution of pulmonary hypertension after return to normoxia (days 22-35) . Mice were sampled during nine time-points and each time-point was replicated 4 times (with dye swapping). Keywords = hypoxia Keywords = pulmonary hypertension

2010-06-10 | E-GEOD-1909 | biostudies-arrayexpress

NHLBI TOPMed: Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease

Project description:NHLBI TOPMed: Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease

| PRJNA490230 | ENA

NHLBI TOPMed: Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease

Project description:NHLBI TOPMed: Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease

| PRJNA490229 | ENA

Hypoxic pulmonary hypertension study

2005-03-16 | GSE1909 | GEO

Changes in Gene Expression Profiles in Patients with Pulmonary Arterial Hypertension Associated with Scleroderma Treated with Tadalafil

Project description:The study looked at changes in gene expression profiles in subjects with Pulmonary Arterial Hypertension and Scleroderma (PAH-SSc) before and after treatment with Tadalafil. A total of ten subjects were enrolled and various clinical assessments including 6-minute walk tes, cardiac MRI and right heart catheterization were done in addition to gene expression study.

2016-08-26 | GSE75173 | GEO

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