Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Hypoxic pulmonary hypertension study

ABSTRACT: These microarray studies were performed using whole lungs of BALB/C mice during development of hypoxia-induced pulmonary hypertension (days 1-21) and resolution of pulmonary hypertension after return to normoxia (days 22-35) . Mice were sampled during nine time-points and each time-point was replicated 4 times (with dye swapping). Keywords = hypoxia Keywords = pulmonary hypertension

ORGANISM(S): Mus musculus

SUBMITTER: Sina Gharib

PROVIDER: E-GEOD-1909 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global gene annotation analysis and transcriptional profiling identify key biological modules in hypoxic pulmonary hypertension.

Gharib Sina A SA Luchtel Daniel L DL Madtes David K DK Glenny Robb W RW

Physiological genomics 20050322 1

Chronic hypoxic pulmonary hypertension is an important clinical disorder causing significant morbidity. Despite recent discoveries, many molecular mechanisms involved in its pathogenesis remain unexplored. We have undertaken a systematic and unbiased approach to gain global insights into this complex process. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified the dominant temporal patterns of gene expression during progression and regress ...[more]

PMID: 15784693

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Dataset Information

Hypoxic pulmonary hypertension study

Publications

Global gene annotation analysis and transcriptional profiling identify key biological modules in hypoxic pulmonary hypertension.

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