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Solobacterium moorei CC14Y

ABSTRACT: Reference genome for the Human Microbiome Project

PROVIDER: PRJNA71575 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR835811_1.fastq.gz	Fastqsanger.gz
	SRR835811_2.fastq.gz	Fastqsanger.gz
	SRR959134_1.fastq.gz	Fastqsanger.gz
	SRR959134_2.fastq.gz	Fastqsanger.gz

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Solobacterium moorei F0204

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Project description:We present five cases of Solobacterium moorei bacteremia. The isolates were identified with 16S rRNA gene sequencing and were susceptible to common antibiotics used for anaerobic infections. Bacteremia with S. moorei seems to be associated with debilitating conditions, but the prognosis of the infection appears to be good.

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First case report of bacteremia caused by Solobacterium moorei in China, and literature review.

Project description:BACKGROUND:Solobacterium moorei, the only species in the genus Solobacterium, is a Gram-positive, non-spore-forming, strict anaerobic, short to long bacillus. It has rarely been documented to cause blood stream infections. Here we report the first case of bacteremia caused by S.moorei in China. CASE PRESENTATION:A 61-year-old male presented to Peking Union Medical College Hospital (Beijing) with thrombotic thrombocytopenic purpura (TTP) and several other underlying diseases. He also had persistent coma accompanied by intermittent convulsions, halitosis, and intermittent fever. Blood cultures taken when the patient had a high fever were positive, with the anaerobic bottle yielding an organism identified as S.moorei by 16S rRNA gene sequencing, whilst the aerobic bottle grew Streptococcus mitis. After replacement of venous pipeline, and empirical use of vancomycin and meropenem, the patient's body temperature and white blood cell count returned to normal. Unfortunately, the patient died of severe TTP. CONCLUSION:This is the first case report of S. moorei isolation from blood stream in China. 16S rRNA gene sequencing is the only method that can identify S. moorei. Blood cultures must be taken before administration of antibiotics, and anaerobic culture should be considered for such rare pathogens in patients with oral diseases and immune deficiency.

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