Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles of WDR4 knockdown in HCC cells

ABSTRACT: Gene expression profiles of WDR4 knockdown in HCC cells

PROVIDER: PRJNA716516 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14041377_1.fastq.gz	Fastqsanger.gz
	SRR14041377_2.fastq.gz	Fastqsanger.gz
	SRR14041378_1.fastq.gz	Fastqsanger.gz
	SRR14041378_2.fastq.gz	Fastqsanger.gz
	SRR14041379_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Gene expression profiles of WDR4 knockdown in HCC cells

Project description:HCC cell line, Huh-7 cells and HCC-LM3 cells, was transfected with sh-WDR4-2 or sh-NC for 48hr to knockdown WDR4 expression, and check the downstream mRNA changes.

2021-07-07 | GSE169394 | GEO

Gene expression profiles of PML knockdown or WDR4 overexpression in A549 cells

Project description:Lung cancer cell line, A549 cells, was transfected with siPML or siCtrl for 48hr to knockdown PML expression. WDR4 or vector was overexpressed in A549 cells for 48hr. These four sets of cells were then subjected to microarray profiling using the Human OneArray microarray (version HOA6.1, GEO Platform GPL19137) from Phalanx Biotech Group. Comparison of transcriptomes from siPML/siCtrl and W4/vec in A549 cells

2016-07-04 | E-GEOD-83499 | biostudies-arrayexpress

Gene expression profiles of PML knockdown or WDR4 overexpression in A549 cells

2016-07-04 | GSE83499 | GEO

Gene expression profiles of PRMT1 knockdown adipocytes

Project description:Gene expression profiles of PRMT1 knockdown adipocytes

| PRJNA808750 | ENA

Expression data from SND1 knockdown clones of human HCC cell line QGY-7703

Project description:Staphylococcal nuclease domain-containing protein 1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) and positively regulates development and progression of HCC. We established stable clones expressing SND1 shRNA in QGY-7703 cells and analyzed the gene expression profiles of a control clone and two SND1 knockdown clones to check what genes are regulated by SND1. Steady-state proliferating cells were collected for RNA extraction and Affymetrix microarray hybridization. Three biological replicates each of a control clone and 2 SND1 knockdown clones.

2013-04-01 | E-GEOD-44601 | biostudies-arrayexpress

Expression data from SOX9 knockdown in HCC cells

Project description:Expression data from SOX9 knockdown in HCC cells

| PRJNA600736 | ENA

Expression data from SND1 knockdown clones of human HCC cell line QGY-7703

2013-04-01 | GSE44601 | GEO

Gene Expression Profiles Associated with Mφ Spatial Aggregation for HCC

Project description:Gene Expression Profiles Associated with Mφ Spatial Aggregation for HCC

| PRJNA1157346 | ENA

The gene expression of HCC cells and HCC cells knocked down TMED3

Project description:We report that TMED3 was up-regulated in HCC and portal vein tumor thrombus. Gene microarray analysis TMED3-knockdown cells and normal HCC cell.

2017-02-09 | GSE88772 | GEO

METTL1/WDR4-mediated tRNA m7G modification and mRNA translation control promotes oncogenesis and doxorubicin resistance in osteosarcoma

Project description:Osteosarcoma is the most common bone tumor that leads to high mortality in adolescents and children. The tRNA N7-methylguanosine methyltransferase METTL1 is located in chromosome 12q14.1, a region that is frequently amplified in osteosarcoma patients, while its functions and underlying mechanisms in regulation of osteosarcoma remain unknown. Herein we show that METTL1 and WDR4 are overexpressed in osteosarcoma and associated with poor patient prognosis. Knockdown of METTL1 or WDR4 causes decreased tRNA m7G modification level and impairs osteosarcoma progression in vitro and in vivo. Conversely, METTL1/WDR4 overexpression promotes osteosarcoma proliferation, migration and invasion capacities. tRNA methylation and mRNA translation profiling indicated that METTL1/WDR4 modified tRNAs enhance translation of mRNAs with more m7G tRNA-decoded codons, including extracellular matrix (ECM) remodeling effectors, which facilitates osteosarcoma progression and chemoresistance to doxorubicin.Our study demonstrates METTL1/WDR4 mediated tRNA m7G modification plays crucial oncogenic functions to enhance osteosarcoma progression and chemoresistance to doxorubicin via alteration of oncogenic mRNA translation, suggesting METTL1 inhibition combined with chemotherapy is a promising strategy for treatment of osteosarcoma patients.

2024-02-01 | GSE225515 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data