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Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model

ABSTRACT: Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model

PROVIDER: PRJNA718063 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR14087900_1.fastq.gz	Fastqsanger.gz
	SRR14087900_2.fastq.gz	Fastqsanger.gz
	SRR14087901_1.fastq.gz	Fastqsanger.gz
	SRR14087901_2.fastq.gz	Fastqsanger.gz

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Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [blood]

Project description:Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [blood]

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Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [brain]

Project description:Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [brain]

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Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [blood]

Project description:Therapeutic development for Huntington's disease (HD) would benefit from a method to monitor disease progression and treatment efficacy, ideally using blood biomarkers. Previously, HD-specific signatures were identified in human blood which adequately represented signatures in human brain, showing biomarker potential. Since drug candidates are normally first screened in rodent models, we aimed to identify HD-signatures in blood and brain of YAC128 HD mice and validate these with our previously identified human signatures. In both brain and blood, we identified HD-associated modules using Weighted Gene Co-expression Network Analysis (WGCNA) representing various biological processes previously associated with HD. Disease-related processes in blood and brain showed substantial overlap, including processes related to protein modification, cell cycle, RNA splicing, nuclear transport and vesicle-mediated transport. Moreover, the disease-associated processes shared between mouse blood and brain were highly comparable to those previously identified in human blood and brain. In addition to shared pathology, we identified HD-associated blood modules showing blood-specific pathology.

2021-12-21 | GSE169405 | GEO

Transcriptomics data of blood and brain from the YAC128 Huntington's disease mouse model [brain]

2021-12-21 | GSE170997 | GEO

Striatum of Huntington's disease model mice [Affymetrix data]

Project description:Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms. Transgenic mice expressing human HD huntingtin with 120 CAG repeats (YAC128) and wildtype littermates were used for the described experiments. The mice were group housed in polystyrene cages under a normal light-dark cycle (6 am to 8 pm) in a clean facility and with free access to water and standard rodent chow. All experiments were performed in accordance with the University of British Columbia animal care committee. Striatal tissue was collected from 12 and 24 month old YAC128 mice and wildtype littermates.

2010-02-21 | E-GEOD-18551 | biostudies-arrayexpress

DNA methylation profiles from a transgenic sheep model of Huntington's disease

Project description:An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from n=168 blood samples of a transgenic sheep model of Huntington's disease. 84 transgenic sheep and age matched control sheep.

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Human blood expression for Huntington's disease versus control

Project description:Affymetrix U133A expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other

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Human blood expression for Huntington's disease versus control

Project description:Affymetrix U133A expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other

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Striatum of Huntington's disease model mice [Affymetrix data]

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Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood

Project description:In this study we investigated the suitability of blood to identify HD transcriptomic biomarkers, validated the outcome in an independent cohort and derived a first empiric panel of biomarkers capable of predicting HD motor scores. Finally we examined whether patient gene expression profiles could provide information about HD affected biological pathways. Examination of differentially expressed genes in peripheral whole blood using linear modelling of gene expression data (3 DGE) against UHDRS total motor scores of Huntington's Disease mutation carriers and controls.

2015-02-02 | E-GEOD-51799 | biostudies-arrayexpress

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