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Coexpression Gene Network Analysis reveals novel regulatory pathways involved in Porto-sinusoidal vascular disease pathophysiology

ABSTRACT: Coexpression Gene Network Analysis reveals novel regulatory pathways involved in Porto-sinusoidal vascular disease pathophysiology

PROVIDER: PRJNA718857 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14119200_1.fastq.gz	Fastqsanger.gz
	SRR14119200_2.fastq.gz	Fastqsanger.gz
	SRR14119201_1.fastq.gz	Fastqsanger.gz
	SRR14119201_2.fastq.gz	Fastqsanger.gz
	SRR14119202_1.fastq.gz	Fastqsanger.gz

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Coexpression Gene Network Analysis reveals novel regulatory pathways involved in Porto-sinusoidal vascular disease pathophysiology

Project description:Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes portal hypertension. It usually affects young individuals and shorts live expectancy. The deregulated pathways involved in PSVD development are unknown and therefore we lack curative treatments. The purpose of this study was to better understand the biological pathology of PSVD integrating transcriptomic and clinical data by comprehensive network-based modeling with the final aim of uncovering altered biological processes in patients with PSVD.

2022-02-11 | GSE171248 | GEO

Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation

Project description:Oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM) can result in vascular liver lesions such as sinusoidal dilatations. Physiopathology remains unclear and variability between patients suggests that there is individual susceptibility. A better understanding of the molecular mechanisms of oxaliplatin liver toxicity may allow to identification of biomarkers and adaptation of chemotherapy delivery. non-tumor frozen liver samples were obtained from patients operated on for CRLM after an exclusive oxaliplatin-based chemotherapy. Gene-expression profiles were first analyzed by microarray on a selected population of 20 patients; 9 patients with severe sinusoidal dilatation (SD) after a short period of chemotherapy and 10 patients without any sinusoidal dilatation after a long period of chemotherapy. These were compared with a control group of 5 patients without any chemotherapy and lesions. This dataset is part of the TransQST collection.

2012-03-01 | E-GEOD-32384 | biostudies-arrayexpress

Transcriptome analysis of human sinusoidal endothelial cells, hepatocyte

Project description:We report the transcriptome human primary hepatocytes and liver sinusoidal endothelial cells. Hepatocytes were obtained from commercial sources. LSECs were isolated based on the coexpression of Tie2 and CD32b, te strategy of purification controlled by RNA-Seq. Comparison of the expression of the Tie-2, CD32b, SELP, FVIII, VWF, Alb, Fg, F7genes

2015-01-01 | E-GEOD-43984 | biostudies-arrayexpress

Rat models for Portosinusoidal Vascular Disease

Project description:Background: Porto-Sinusoidal Vascular Disorder (PSVD) involves a group of rare vascular liver diseases of unknown etiology that leads to the development of portal hypertension and its life-threatening complications. Its pathophysiology is not well understood and animal models described to date do not fully recapitulate human disease. Methods: We developed 3 different PSVD rat models by either immunosensitization (repetitive intraportal LPS or intramuscular spleen extract injections) or toxic (combination of FOLFOX and a selenium-enriched diet, Selfox model) treatment and characterized them at hemodynamic, histological, biochemical and transcriptional levels. We compared these results to human data. Results: All three models developed significant portal hypertension, while only the LPS and the Selfox models displayed PSVD specific and non-specific histological alterations in the absence of cirrhosis. Transcriptional comparison between rat animal models and human data showed both LPS and Selfox models recapitulate the main transcriptional alterations observed in humans, especially regarding hemostasis, oxidative phosphorylation and cell cycle regulation. Reproducibility and feasibility was higher for the Selfox model. Conclusions: The Selfox rat model faithfully reproduces the main alterations described in PSVD. Its use as a preclinical model for drug testing in progressing PSVD can be a significant step forward towards development of new therapeutic targets for this rare condition.

2024-03-14 | GSE229380 | GEO

Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation

2012-03-01 | GSE32384 | GEO

Transcriptome analysis of human sinusoidal endothelial cells, hepatocyte

2015-01-01 | GSE43984 | GEO

Gene expression analysis of vascular pathophysiology related to anti-TNF treatment in rheumatoid arthritis

Project description:Gene expression analysis of vascular pathophysiology related to anti-TNF treatment in rheumatoid arthritis

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Expression data from mouse bone marrow sinusoidal endothelial cells (SECs) before and after the ablation of classical dendrtic cells (cDCs)

Project description:The function of bone marrow sinusoidal endothelial cells may change upon the ablation of classical dendritic cells to promote vascular permeability and angiogenesis

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Expression data from Notch intracellular domain overexpressing primary murine liver sinusoidal endothelial cells

Project description:Liver sinusoidal endothelial cells (LSEC) constitute discontinuous, permeable microvessels, with a characteristic programme of gene expression that differs significantly from continuous microvascular endothelial cells e.g. in the lung. Notch signalling plays a crucial role in a variety of processes in endothelial cells such as vascular morphogenesis, and vascular differentiation. We used microarrays to analyse the programme of gene expression in murine liver endothelial cells with enhanced Notch signalling.

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Normal and injured liver sinusoidal endothelial cells

Project description:Comparison of C57BL/6J 8-10 weeks male mouse liver sinusoidal endothelial cells (LSEC) from normal liver and from liver injured by carbon tetrachloride administration. Keywords: other

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