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CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

ABSTRACT: CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

PROVIDER: PRJNA721296 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14212070_1.fastq.gz	Fastqsanger.gz
	SRR14212070_2.fastq.gz	Fastqsanger.gz
	SRR14212071_1.fastq.gz	Fastqsanger.gz
	SRR14212071_2.fastq.gz	Fastqsanger.gz

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CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

Project description:Therapies against glioblastoma multiforme (GBM) have been largely ineffective due to the infiltration of immunosuppressive tumor-associated macrophages (TAMs). Recent studies demonstrated that TAMs can also be immune-activating. However, markers differentiating these heterogeneous macrophage populations have not been established. In this study, we identified a subset of macrophages expressing CD169 that promote an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we found that CD169+ macrophages in human and mouse gliomas produced proinflammatory chemokines, leading to the accumulation of T cells and NK cells. Depletion of CD169+ macrophages shortened the survival of mice with gliomas and reduced the function of antitumor lymphocytes. We show that IFN-γ produced by NK cells was critical for the accumulation of CD169+ macrophages into gliomas. Additionally, CD169 expression on macrophages increased the phagocytosis of apoptotic glioma cells. Our finding suggests that the CD169+ subset of TAMs promotes antitumor immune responses against GBM.

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Project description:Tingible body macrophages (TBMs) exist in lymph node B cell follicles and are responsible for clearing apoptotic B cells. Our data suggests that TBMs are of Cd169-lineage. We isolated cells from Cd169Cre/+.Tdtomatofl/fl reporter mice and transcriptionally profiled them to identify putative TBMs and chacterise their development and function relative to other LN cells of the Cd169 lineage.

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