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CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [EGFRviii]

ABSTRACT: CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [EGFRviii]

PROVIDER: PRJNA832228 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18923397.fastq.gz	Fastqsanger.gz
	SRR18923398.fastq.gz	Fastqsanger.gz

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Similar Datasets

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [EGFRviii]

Project description:Therapies against glioblastoma multiforme (GBM) have been largely ineffective due to the infiltration of immunosuppressive tumor-associated macrophages (TAMs). Recent studies demonstrated that TAMs can also be immune-activating. However, markers differentiating these heterogeneous macrophage populations have not been established. In this study, we identified a subset of macrophages expressing CD169 that promote an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we found that CD169+ macrophages in human and mouse gliomas produced proinflammatory chemokines, leading to the accumulation of T cells and NK cells. Depletion of CD169+ macrophages shortened the survival of mice with gliomas and reduced the function of antitumor lymphocytes. We show that IFN-γ produced by NK cells was critical for the accumulation of CD169+ macrophages into gliomas. Additionally, CD169 expression on macrophages increased the phagocytosis of apoptotic glioma cells. Our finding suggests that the CD169+ subset of TAMs promotes antitumor immune responses against GBM.

2022-08-24 | GSE201557 | GEO

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [CT2A]

2022-09-11 | GSE201553 | GEO

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

2022-09-11 | GSE171872 | GEO

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor

Project description:CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor

| PRJNA832219 | ENA

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [CT2A]

Project description:CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [CT2A]

| PRJNA832218 | ENA

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

Project description:CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor [WG vs TG]

| PRJNA721296 | ENA

CD169 is a marker of IFN-γ-stimulated inflammatory macrophages in brain tumor

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-25 | GSE201559 | GEO

EGFRvIII/STAT3 targets in glioblastoma pathogenesis

Project description:Next generation sequencing platforms were used to identify STAT3 targets in the background of EGFRvIII expresssion mRNA of 3 EGFRvIII positive brain tumor stem cell lines (BTSC #68, 73, and 90) were compared to an EGFRvIII negative line (#41) to identify EGFRvIII-regulated targets in human BTSC. EGFRvIII-dependent targets in mouse astrocytes were identified by mRNA-seq analyses of EGFRvIII- or MSCV-expressing astrocytes. STAT3-differentially regulated genes in EGFRvIII expressing mouse astrocytes were obtained by subjecting EGFRvIII,STAT3f/f and EGFRvIII, STAT3-/- astrocytes to mRNA-Seq analyses. Sites of STAT3 occupancy in EGFRvIII expressing astrocytes were identified by ChIP-Seq using a STAT3 antibody or IgG control. We identified OSMR as a direct target of STAT3 in both EGFRvIII-expressing human BTSC and mouse astrocytes. Therefore to identify OSMR-regulated genes, we used a lentiviral mediated RNAi system to knockdown OSMR in EGFRvIII-expressing astrocytes. OSMR-dependent differentially expressed genes were obtained by comparison of OSMR knockdown (KD1 and KD2) astrocytes to control groups (ShRNA control and Vector control)

2016-04-13 | E-GEOD-51281 | biostudies-arrayexpress

Proteomic analysis of human eosinophils stimulated with IFN-gamma and IL-5

Project description:Activated eosinophils is a major cell type to be involved in allergic diseases.IL-5 primarily activates eosinophils and prolongs their survival. However, IFN-gamma is also important as an activator for the cells. The aim of this study is to clarify the role of these cytokines as direct activators for human eosinophils.

2024-06-20 | PXD052615 | JPOST Repository

Transcriptional profiling of Cd169-lineage lymph node macrophages

Project description:Tingible body macrophages (TBMs) exist in lymph node B cell follicles and are responsible for clearing apoptotic B cells. Our data suggests that TBMs are of Cd169-lineage. We isolated cells from Cd169Cre/+.Tdtomatofl/fl reporter mice and transcriptionally profiled them to identify putative TBMs and chacterise their development and function relative to other LN cells of the Cd169 lineage.

2023-02-16 | GSE214060 | GEO

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