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Young blood-derived platelet factors abate inflammation and rescue recognition in aging.

ABSTRACT: Young blood-derived platelet factors abate inflammation and rescue recognition in aging.

PROVIDER: PRJNA724981 | ENA |

REPOSITORIES: ENA

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Young blood-derived platelet factors abate inflammation and rescue recognition in aging.

Project description:We show that platelet factors transfer rejuvenating effects of young plasma to the aging brain. Proteomic analysis of plasma from young and aged mice identified age-related changes in platelets. Systemic exposure of aged animals to the platelet fraction of young plasma decreased hippocampal neuroinflammation at a transcriptional and cellular level and ameliorated cognitive impairments. We identified the platelet-derived chemokine CXCL4/Platelet Factor-4 (PF4) as a pro-youthful circulating factor. Systemic PF4 administration decreased age-related neuroinflammation, restored the aging peripheral immune system to a more youthful state, and improved hippocampal-dependent learning and memory in aged mice.

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YOUNG BLOOD-DERIVED PLATELET FACTORS ATTENUATE INFLAMMATION AND RESCUE COGNITION IN AGING

Project description:YOUNG BLOOD-DERIVED PLATELET FACTORS ATTENUATE INFLAMMATION AND RESCUE COGNITION IN AGING

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YOUNG BLOOD-DERIVED PLATELET FACTORS ATTENUATE INFLAMMATION AND RESCUE COGNITION IN AGING

Project description:Platelet-derived factors in young blood decrease neuroinflammation and enhance cognitive function in the aged hippocampus.

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Platelet factor 4 (PF4) is induced by klotho and rejuvenates cognition and its molecular signature in the aging hippocampus

Project description:Platelet factors regulate wound healing and also signal from the blood to the brain. However, whether platelet factors modulate cognition, a highly valued and central manifestation of brain function, is unknown. Here, we show that systemic platelet factor 4 (PF4) modulates cognition and its molecular signature. Klotho, a longevity and cognition-enhancing protein, acutely activated platelets and increased circulating platelet factors, most robustly platelet factor 4 (PF4). To directly test PF4 effects on the brain, we treated mice with vehicle or systemic PF4. In young mice, PF4 enhanced synaptic plasticity and cognition. In aging mice, PF4 restored cognitive deficits and rejuvenated a molecular signature of cognition in the aging hippocampus. Augmenting platelet factors such as PF4, a possible messenger of klotho, may enhance cognition in the young brain and rejuvenate cognitive deficits in the aging brain.

2023-06-24 | GSE171929 | GEO

HuR coordinates systemic aging through platelet infiltration

Project description:Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in sys temic aging. In aged mice, the levels of platelet secreted pro inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in brain, liver, lung, kidney, and aortic root. The RNA binding protein HuR/ELAVL1, a major regulator of R NA metabolism, promoted the production of PSPF in platelets. Platelet specific deletion of HuR reduced the expression of PSPF in platelets, alleviated platelet infiltration in brain, liver, lung, kidney, and aortic root, and delayed systemic aging. Our findings highlight a role of platelets in coordinating aging traits across organs.

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HuR coordinates systemic aging through platelet infiltration

Project description:HuR coordinates systemic aging through platelet infiltration

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Mass spectrometry data of Platelet-rich plasma from 6 young and 6 elderly individuals

Project description:We prepared platelet-rich plasma from the blood of 6 young volunteers and 6 elderly volunteers, respectively, and removed 95% of high-abundance proteins, followed by mass spectrometry analysis.

2024-04-24 | PXD050061 | Pride

Platelet-rich plasma in young and elderly human exhibit a different proteomic profile

Project description:we prepared platelet-rich plasma from the blood of 6 young volunteers and 6 elderly volunteers, respectively, and removed 95% of high-abundance proteins, followed by mass spectrometry analysis.

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Rna_seq analysis of aorta in young and aging mice

Project description:Analyzing the aortic transcriptome of young and aged mice can help reveal the differences in vascular transcriptome during aging in mice. Moreover, this dataset can provide a basis for cross-species transcriptome comparison

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Gene expresion analysis among young mouse embryos, aging mouse embryos and aging mouse embryos suppressed their CXCL5-CXCR2 signaling.

Project description:CXCL5-CXCR2 signailing is known as senescence-associated secretory phenotype (SASP) factor to promote cellular senescense in diverse cells. We identified CXCL5 as a SASP factor in human and mouse embryos and suppression of CXCL5-CXCR2 signaling during embryo culture improved pregnancy success in aging mice. Here, we perfomed microarray analysis using mouse blastocysts for comparing gene expression pattarns among young mouse embryos, aging mouse embryos and aging mouse embryos suppressed their CXCL5-CXCR2 signaling. As a results, gene expression pattern of CXCL5-CXCR2 signaling-suppressed aging blastocysts was closer to that of the young blastocysts as compared with aging blastocysts. In addition, cell proliferation-related pathways, such as “PI3K signaling pathway” and “RAS signaling pathway” were significantly enriched in CXCL5-suppressed blastocysts.

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