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Nucleolin HITS-CLIP, RNA-Seq and Ribo-Seq upon inhibition of 5'-tRFCys

ABSTRACT: Nucleolin HITS-CLIP, RNA-Seq and Ribo-Seq upon inhibition of 5'-tRFCys

PROVIDER: PRJNA725264 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14327719_1.fastq.gz	Fastqsanger.gz
	SRR14327719_2.fastq.gz	Fastqsanger.gz
	SRR14327720_1.fastq.gz	Fastqsanger.gz
	SRR14327720_2.fastq.gz	Fastqsanger.gz
	SRR14327721_1.fastq.gz	Fastqsanger.gz

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Nucleolin HITS-CLIP, RNA-Seq and Ribo-Seq upon inhibition of 5'-tRFCys

Project description:Expression of 5'-tRFCys is significantly upregulated during breast cancer metastasis and suppression of 5'-tRFCys significantly reduced metastatic lung colonization of breast cancer. We identified Nucleolin (Ncl) as the direct binding partner of 5'-tRFCys. To identify the molecular mechanism underlying 5'-tRFCys promotion of breast cancer, we performed Ncl HITS-CLIP, RNA-Seq, Ribosome profiling (Ribo-Seq) upon inhibition of 5'-tRFCys. These analyses reveal that 5'-tRFCys enhances Ncl binding to a subset of transcripts, resulting in increased transcript stability of those transcripts and expression.

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