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Characterization of the transcriptomic profile of Plagl1+/-pat retina

ABSTRACT: Characterization of the transcriptomic profile of Plagl1+/-pat retina

PROVIDER: PRJNA727582 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14434300.fastq.gz	Fastqsanger.gz
	SRR14434301.fastq.gz	Fastqsanger.gz
	SRR14434302.fastq.gz	Fastqsanger.gz
	SRR14434303.fastq.gz	Fastqsanger.gz
	SRR14434304.fastq.gz	Fastqsanger.gz

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Characterization of the transcriptomic profile of Plagl1+/-pat retina

Project description:Retinal damage triggers reactive gliosis in Müller glia across vertebrate species, but only in regenerative animals, such as teleost fish, do Müller glia initiate repair; proliferating and undergoing neurogenesis to replace lost cells. We found that Plagl1, a maternally imprinted gene, is dynamically regulated in reactive Müller glia post-insult, with transcript levels transiently increasing before stably declining. To study Plagl1 retinal function, we examined Plagl1+/-pat null mutants postnatally, revealing defects in retinal architecture, visual signal processing and a reactive gliotic phenotype. Plagl1+/-pat Müller glia proliferate ectopically and give rise to inner retinal neurons and photoreceptors. Transcriptomic and ATAC-seq profiles revealed similarities between Plagl1+/-pat retinas and neurodegenerative and injury models, including an upregulation of pro-gliogenic and pro-proliferative pathways, such as Notch, not observed in wild-type retinas Plagl1 is thus an essential component of the transcriptional regulatory networks that retain mammalian Müller glia in quiescence.

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Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

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Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

Project description:Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

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Gene expression profile at single cell level of Wild type and Plagl1 knock out retina at P7

Project description:Plagl1 controls Muller glial cells proliferation in the retina. We used single cell RNA sequencing (scRNA-seq) to analyze the prolirative state of Muller glial cells and identify the signals that might be involved in this process

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Gene expression profile at single cell level of Wild type and Plagl1 knock out retina at P7

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Transcriptome sequencing (RNA-Seq) of PAT cells in CAD and control patients for exploring the association between CAD and PAT

Project description:Coronary artery disease (CAD) poses a worldwide health threat. Compelling evidence shows that pericardial adipose tissue (PAT), a brown-like adipose adjacent to the external surface of the pericardium, is associated with CAD. However, the specific molecular mechanisms of PAT in CAD are elusive. For characterizing human PAT and explore its association with CAD, the transcriptome characteristics were assessed in 5 CAD patients and 4 controls via RNA-sequencing.

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