Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

USP12-repressed genes in lung adenocarcinoma cells

ABSTRACT: USP12-repressed genes in lung adenocarcinoma cells

PROVIDER: PRJNA728108 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14466786_1.fastq.gz	Fastqsanger.gz
	SRR14466786_2.fastq.gz	Fastqsanger.gz
	SRR14466787_1.fastq.gz	Fastqsanger.gz
	SRR14466787_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

USP12-repressed genes in lung adenocarcinoma cells

Project description:The study aims at elucidating the effects of the deubiquitinase USP12 on lung tumorigenesis and malignant progression. To obtain molecular details of how USP12 functions in lung tumor cells, we profiled the genes transcriptionally affected by USP12 knockdown.

2021-06-13 | GSE174078 | GEO

Ito2019 - gefitnib resistance of lung adenocarcinoma caused by MET amplification

Project description:The model is based on publication: Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification Abstract: Gefitinib, one of the tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR), is effective for treating lung adenocarcinoma harboring EGFR mutation; but later, most cases acquire a resistance to gefitinib. One of the mechanisms conferring gefitinib resistance to lung adenocarcinoma is the amplification of the MET gene, which is observed in 5–22% of gefitinib-resistant tumors. A previous study suggested that MET amplification could cause gefitinib resistance by driving ErbB3-dependent activation of the PI3K pathway. In this study, we built a mathematical model of gefitinib resistance caused by MET amplification using lung adenocarcinoma HCC827-GR (gefitinib resistant) cells. The molecular reactions involved in gefitinib resistance consisted of dimerization and phosphorylation of three molecules, EGFR, ErbB3, and MET were described by a series of ordinary differential equations. To perform a computer simulation, we quantified each molecule on the cell surface using flow cytometry and estimated unknown parameters by dimensional analysis. Our simulation showed that the number of active ErbB3 molecules is around a hundred-fold smaller than that of active MET molecules. Limited contribution of ErbB3 in gefitinib resistance by MET amplification is also demonstrated using HCC827-GR cells in culture experiments. Our mathematical model provides a quantitative understanding of the molecular reactions underlying drug resistance.

2024-09-02 | BIOMD0000000827 | BioModels

Transcriptomic analyses of lung adenocarcinoma cells

Project description:Transcriptomic analyses of lung adenocarcinoma cells

| PRJNA843347 | ENA

MeRIP-sequencing in lung adenocarcinoma cells

Project description:MeRIP-sequencing in lung adenocarcinoma cells

| PRJNA719778 | ENA

Transcriptomic analyses of lung adenocarcinoma cells and genome-wide maps of chromatin state in lung adenocarcinoma cells

Project description:Transcriptomic analyses of lung adenocarcinoma cells and genome-wide maps of chromatin state in lung adenocarcinoma cells

| PRJNA756032 | ENA

Proteomic Identification of Lung Adenocarcinoma and Normal Lung Tissue

Project description:To identify proteomic of lung adenocarcinoma, we collected five pairs of lung adenocarcinoma and normal lung tissues from the clinic for analysis

2022-01-12 | PXD027008 | Pride

Lung adenocarcinoma methylation analysis.

Project description:Lung adenocarcinoma methylation analysis.

| PRJNA911747 | ENA

expression data from human lung adenocarcinoma cells A549

Project description:expression data from human lung adenocarcinoma cells A549

| PRJNA411770 | ENA

USP12-induced gene expression in lung adenocarcinoma cells

Project description:USP12-induced gene expression in lung adenocarcinoma cells

| PRJNA659656 | ENA

Chromatin changes in G9a inhibited lung adenocarcinoma cells

Project description:Chromatin changes in G9a inhibited lung adenocarcinoma cells