Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Bacillus sp. DU-106 affect Mus musculus albus colonic contents Raw sequence reads

PROVIDER: PRJNA730997 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14590911_1.fastq.gz	Fastqsanger.gz
	SRR14590911_2.fastq.gz	Fastqsanger.gz
	SRR14590912_1.fastq.gz	Fastqsanger.gz
	SRR14590912_2.fastq.gz	Fastqsanger.gz
	SRR14590913_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

Supplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Project description:Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley rats received a high-fat diet, or a high-fat diet supplemented with 7.5 × 109 and 1.5 × 1010 CFU/kg bw/day Bacillus sp. DU-106 (low-dose and high-dose groups). At the end of 9 weeks, Bacillus sp. DU-106 treatment significantly decreased the body weight, liver index, and total cholesterol. 16S rRNA sequencing showed that Bacillus sp. DU-106 intervention significantly increased bacterial richness and particularly increased the genus abundance of Turicibacter, Acinetobacter, Brevundimonas, and Bacillus and significantly decreased the abundance of Ralstonia. Metabolomic data further indicated that the supplementation of Bacillus sp. DU-106 remarkably changed the gut metabolic profiles of hypercholesterolemic rats and, in particular, elevated the metabolites of indole-3-acetate, methylsuccinic acid, creatine, glutamic acid, threonine, lysine, ascorbic acid, and pyridoxamine. Spearman's correlation analysis showed the close relation between the different genera and metabolites. In conclusion, Bacillus sp. DU-106 supplement ameliorated high-fat diet-induced hypercholesterolemia and showed potential probiotic benefits for the intestine.KEY POINTS: • A novel potential probiotic Bacillus sp. DU-106 ameliorated hypercholesterolemia in rats. • Bacillus sp. DU-106 supplement regulated gut microbiome structure and richness. • Bacillus sp. DU-106 supplement changed metabolic profiles in high-fat diet rats. • Significant correlations were observed between differential genera and metabolites.

2021-04-08 | MTBLS1168 | MetaboLights

Project description:Dendrobium officinale affect Mus musculus albus colonic contents Raw sequence reads

| PRJNA778606 | ENA

Project description:Compound Probiotics affect antibiotic-associated diarrhea Mus musculus albus colonic contents Raw sequence reads

| PRJNA660873 | ENA

Project description:Chinese yam (Dioscorea opposita Thunb.) polysaccharide affect Mus musculus albus colonic contents Raw sequence reads

| PRJNA598332 | ENA

Bacillus sp. DU-106

Project description:Bacillus sp. DU-106 Genome sequencing

| PRJNA432450 | ENA

Project description:Polysaccharides from Sacha Inchi shell affect Mus musculus albus caecum contents Raw sequence reads

| PRJNA1099161 | ENA

Project description:Dendrobium officinale affect Mus musculus albus liver transcriptome

| PRJNA778883 | ENA

Contrasting patterns of expression divergence in early and late stages of population divergence in mice

Project description:We compared gene expression differences in the polytypic species complex Mus musculus (Mus musculus musculus, Mus musculus domesticus, Mus musculus castaneus and Mus musculus ssp) with that of Mus spretus via oligonucleotide microarrays representing more than 20,000 genes. Analysis of the results by two way ANOVA statistics suggests that the most genes with significant differences in expression levels among the subspecies are found in liver and kidney and the least in testis. This picture is different when one compares with Mus spretus, where the largest number of differences is found in testis. Keywords: multi-species comparison

2006-12-13 | GSE2597 | GEO

Mus musculus breed:C57BL/6J

Project description:Mus musculus Colonic contents 16S rDNA Raw sequence reads

| PRJNA997003 | ENA

rat gut metagenome

Project description:Rattus norvegicus albus colonic contents Raw sequence reads

| PRJNA541098 | ENA