Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Tumor - breast cancer RNA-seq]

ABSTRACT: Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Tumor - breast cancer RNA-seq]

PROVIDER: PRJNA731483 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14605800_1.fastq.gz	Fastqsanger.gz
	SRR14605800_2.fastq.gz	Fastqsanger.gz
	SRR14605801_1.fastq.gz	Fastqsanger.gz
	SRR14605801_2.fastq.gz	Fastqsanger.gz
	SRR14605802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 76

Similar Datasets

Bariatric surgery mediated weight loss reduces breast cancer risk by reducing estrogen receptor alpha activity

Project description:Bariatric surgery mediated weight loss has been shown to significantly reduce breast cancer incidence in women. We hypothesize that loss of excessive adiposity, reduces net Estrogen Receptor Alpha activation which in turn lowers breast cancer risk. A differential gene expression analysis and subsequent pathway enrichment analysis would reveal the relevant molecular mechanism behind the preventive effect of weight loss. We will correlate our RNASeq data findings with serum and breast tissue concentration of hormones as well as expression of proteins regulating hormone synthesis in breast. For this study, we recruited 30 patients who were prescribed baritaric surgery and met our selection criteria (no familial or personal history of breast cancer and free of other confounding conditions). Breast tissue and blood was collected at the day of surgery and at follow up after the patient lost 25% excess body weight. The breast core biopsy was preserved in RNALater till rna isolation and library preparation.

2022-02-20 | GSE126803 | GEO

Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy

Project description:Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy

| PRJNA731481 | ENA

Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Tumor - breast cancer RNA-seq]

Project description:Patients undergoing bariatric surgery are protected from subsequent breast cancer risk. It is unknown whether weight loss alone or surgery-specific alterations mediate risk reduction. We examined breast cancer in a pre-clinical model of diet induced obesity (DIO) followed by vertical sleeve gastrectomy (VSG) or dietary weight loss. DIO exacerbated tumor progression compared to lean controls, while VSG-induced weight loss reversed this exacerbation. However, dietary interventions were more effective than VSG despite similar reductions in weight and adiposity, potentially due to elevated immunosuppression after VSG. In tumor bearing mice, anti-PD-L1 immunotherapy after VSG improved anti-tumor immunity and potently impaired tumor progression. Thus, weight loss before tumor onset was protective regardless of intervention. Importantly, immunotherapy specifically improved outcomes in VSG.

2021-05-21 | GSE174761 | GEO

Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Mammary Fat Pad RNA-seq]

2021-05-21 | GSE174760 | GEO

Bariatric surgery mediated weight loss reduces breast cancer risk by reducing estrogen receptor alpha activity

Project description:Bariatric surgery mediated weight loss reduces breast cancer risk by reducing estrogen receptor alpha activity

| PRJNA523368 | ENA

Bariatric surgery and breast cancer

Project description:This is a double blind study, to measure short chain fatty acids in colons of mouse that have gone through bariatric surgery and the mouse that have gone through sham surgery (as control group). We would like to get a ratio of different types of fatty acids in the colons of these animals. This project looks at the effects of bariatric surgery on short chain fatty acids produced by microbiota ultimately the effects on the growth and suppression of breast cancer.

2017-06-19 | ST000727 | MetabolomicsWorkbench

Bariatric surgery

Project description:Bariatric surgery Targeted loci environmental

| PRJNA1041054 | ENA

Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Mammary Fat Pad RNA-seq]

Project description:Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Mammary Fat Pad RNA-seq]

| PRJNA731484 | ENA

Bariatric Surgery

Project description:Projection of gut microbiome pre and post bariatric surgery to predict surgery outcome

| PRJEB39382 | ENA

bariatric surgery

Project description:Effect of bariatric surgery on microbiome composition and microbial metabolomics.