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Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy

ABSTRACT: Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy

PROVIDER: PRJNA731481 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14605800_1.fastq.gz	Fastqsanger.gz
	SRR14605800_2.fastq.gz	Fastqsanger.gz
	SRR14605801_1.fastq.gz	Fastqsanger.gz
	SRR14605801_2.fastq.gz	Fastqsanger.gz
	SRR14605802_1.fastq.gz	Fastqsanger.gz

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Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Tumor - breast cancer RNA-seq]

Project description:Patients undergoing bariatric surgery are protected from subsequent breast cancer risk. It is unknown whether weight loss alone or surgery-specific alterations mediate risk reduction. We examined breast cancer in a pre-clinical model of diet induced obesity (DIO) followed by vertical sleeve gastrectomy (VSG) or dietary weight loss. DIO exacerbated tumor progression compared to lean controls, while VSG-induced weight loss reversed this exacerbation. However, dietary interventions were more effective than VSG despite similar reductions in weight and adiposity, potentially due to elevated immunosuppression after VSG. In tumor bearing mice, anti-PD-L1 immunotherapy after VSG improved anti-tumor immunity and potently impaired tumor progression. Thus, weight loss before tumor onset was protective regardless of intervention. Importantly, immunotherapy specifically improved outcomes in VSG.

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Project description:Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Tumor - breast cancer RNA-seq]

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Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy

Project description:This SuperSeries is composed of the SubSeries listed below. -GEO GSE174760 (bulk mammary fat pad RNA), GSE174761 (bulk tumor RNA),

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