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MiRNA expression data from sedentary and exercised rats

ABSTRACT: miRNA expression data from sedentary and exercised rats

PROVIDER: PRJNA732210 | ENA |

REPOSITORIES: ENA

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miRNA expression data from sedentary and exercised rats

Project description:Loss of skeletal muscle mass during aging, also known as sarcopenia, is a worldwide health problem. The etiology of sarcopenia remains unknown; however, recent studies revealed that sedentarism, fat gain, and epigenetic regulators such as miRNAs are critical regulators in its developing. One effective intervention to prevent and treat sarcopenia is aerobic exercise. We used miRNA microarrays to determine the changes in miRNA expression through time and the differences between sedentary and lifelong exercised rats.

2021-05-24 | GSE175390 | GEO

Gene expression profile at single cell level of whole melanoma tumor dissociations taken from sedentary or exercised mice

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Transcription profiling of heart tissue from rats that have undergone treadmill exercise or have been sedentary for different lengths of time

Project description:Seventy two rats were randomized to twelve independent groups of rats (n = 6 in all groups) where half of the rats were chosen for training (treadmill exercise training 1.5 hour 5 days a week, in 1, 4, 24, 48 days and for 4 and 8 weeks) or sedentary (no training) as described in detail by Wisloff et al. (Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.) or Kemi et al.(Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation. 2004 Jun 15;109(23):2897-904. Epub 2004 Jun 1.). The rats were scarified one hour after training (1, 4, 24 and 48 days) or 24 hours after training (4 and 8 weeks). Biopsies form left ventricle was taken form all rats and stored on -80°C for preparation of RNA. The same procedures were performed for the control/sedentary rats which were sacrificed at the same time as the exercised rats.

2006-11-10 | E-TABM-166 | biostudies-arrayexpress

Transcriptomic signatures of exercised tendon in male rats

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Single cell RNA sequencing of skeletal muscle endothelial cells in sedentary and exercised mice

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Gene expression analysis of hyper active mutant SPORTS rat [muscle]

Project description:To get insight into the genetic characteristics of hyper active mutant line of rat, SPORTS, and the effect of exercise on gene expression, we compared gene expression profiles of exercised SPORTS rat, sedentary SPORTS rat, and sedentary wild type rat. Using RNA extracted from the muscle of these rats, we performed microarray analysis. Subsequent GO analyses revealed that genes belonging to muscle development and glycolysis were upregulated in exercised SPORTS rat compared to sedentary SPORTS rat, and genes related to coagulation were upreguated in sedentary SPORTS rat compared to wild type rat. These results were consistent with phenotypes, such as hyper activity and thrombotic tendency, which were reported for SPORTS rat.

2018-11-01 | GSE88853 | GEO

Myocardial proteome changes in aortic stenosis rats subjected to long-term aerobic exercise

Project description:The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study we analyzed the myocardial proteome to identify proteins modulated by moderate intensity aerobic ET in rats with chronic supravalvar AS. Wistar rats were divided into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary aortic stenosis (AS-Sed), and exercised AS (AS-Ex). ET consisted of five treadmill running sessions per week for 16 weeks. Statistical analysis was performed by ANOVA or Kruskal-Wallis and Goodman tests. Results were discussed at a significance level of 5%. At the end of the experiment, AS-Ex rats had higher functional capacity, lower blood lactate concentration, and better cardiac structural and left ventricular functional parameters than the AS-Sed. Myocardial proteome analysis showed that AS-Sed had higher protein expressions related to the glycolytic pathway, oxidative stress, and inflammation, and lower protein expressions related to beta-oxidation than C-Sed. AS-Ex had higher expression of one protein related to mitochondrial biogenesis and lower protein expressions associated with oxidative stress and inflammation than AS-Sed. Proteomic data were validated for proteins related to lipid and glycolytic metabolism. In conclusion, chronic pressure overload changes the expression of myocardial proteins that are mainly involved in lipid and glycolytic energy metabolism in rats. Moderate intensity aerobic training attenuates protein expressions related to oxidative stress and inflammation and increases protein expressions related to mitochondrial biogenesis. Protein changes are associated with improved functional capacity, cardiac remodeling and left ventricular function in aortic stenosis rats.

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Gene expression profile at single cell level of whole melanoma tumor dissociations taken from sedentary or exercised mice

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S-nitrosoproteome of subsarcolemmal mitochondria and cytosolic subfractions from the heart of sedentary and exercise-trained rats.

Project description:This project is the study of S-nitrosylated proteins in SSM and cytosolic subfractions from heart of sedentary and exercise trained rats. Iodoacetyl Tandem Mass Tag (TMT) and TMT-peptide enrichment coupled with liquid chromatography-tandem mass spectrometry analysis have been used to analyze the modified cysteine residues. Comparisons were performed to reveal the impact of exercise training on protein S-nitrosylation.

2022-04-23 | PXD023515 | Pride

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