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Quantitative Analysis of Erythroblast Transcriptomes in Control and NUP-17d Treatment Groups

ABSTRACT: Quantitative Analysis of Erythroblast Transcriptomes in Control and NUP-17d Treatment Groups

PROVIDER: PRJNA736071 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14760912.fastq.gz	Fastqsanger.gz
	SRR14760913.fastq.gz	Fastqsanger.gz
	SRR14760914.fastq.gz	Fastqsanger.gz
	SRR14760915.fastq.gz	Fastqsanger.gz
	SRR14760916.fastq.gz	Fastqsanger.gz

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Quantitative Analysis of Erythroblast Transcriptomes in Control and NUP-17d Treatment Groups

Project description:NUP-17d (17d) is an effective inhibitor of Plek2 protein. NUP-17d treatment inhibits erythroblast proliferation, differentiation and enucleation in a dose-dependent manner via directly binding to Plek2 protein. To reveal the detailed involving mechanism of NUP-17d treatment, we performed RNA sequencing to analyze the gene expression profiles change in erythroblasts which were treated with NUP-17d or DMSO (NC) for 48 hours in the EPO induction culture system.

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