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Next Generation Sequencing of endothelial cells (HUVECs) after treatment by conditioned media obtained from gastric cancer anoikis resistant(GCAR) cells in the presence or absence of neutralizing antibody against PDGFB

ABSTRACT: Next Generation Sequencing of endothelial cells (HUVECs) after treatment by conditioned media obtained from gastric cancer anoikis resistant(GCAR) cells in the presence or absence of neutralizing antibody against PDGFB

PROVIDER: PRJNA736261 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14765828_1.fastq.gz	Fastqsanger.gz
	SRR14765828_2.fastq.gz	Fastqsanger.gz
	SRR14765829_1.fastq.gz	Fastqsanger.gz
	SRR14765829_2.fastq.gz	Fastqsanger.gz
	SRR14765830_1.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing of endothelial cells (HUVECs) after treatment by conditioned media obtained from gastric cancer anoikis resistant(GCAR) cells in the presence or absence of neutralizing antibody against PDGFB

Project description:To identify the dominant signaling events downstream of GCAR-derived PDGFB in HUVECs，we performed RNA sequencing (RNA-seq) in HUVECs treated by conditioned media obtained from GCAR cells in the presence or absence of neutralizing antibody against PDGFB. The RNA-seq data shows that GCAR cells derived PDGFB may promote angiogenesis through MAPK/ERK signaling pathway.

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Adaptive anoikis resistance promotes ovarian cancer metastasis

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Genome-wide maps in PDGFB-induced glioma

Project description:We performed genome-wide profiling of oligodendrocyte lineage transcription factor 2 (Olig2) and other histone markers in platelet-derived growth factor subunit B (PDGFB)-induced glioma and genome-occupancy analyses coupled with transcriptome profiling to reveal gene regulatory network. Examination of Olig2, H327Ac, and H3K4me3 genome-wide occupancy in PDGFB-induced Ctrl-T and Olig2cKO brain tumors (gliomas).

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RNAseq of Pdgfb' brain cells obtained by from young male mice

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PDGFB-expressing MSCs improve human hematopoietic stem cell engraftment in immunodeficient mice

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Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability [scATAC-Seq]

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