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Genome-wide maps in PDGFB-induced glioma

ABSTRACT: We performed genome-wide profiling of oligodendrocyte lineage transcription factor 2 (Olig2) and other histone markers in platelet-derived growth factor subunit B (PDGFB)-induced glioma and genome-occupancy analyses coupled with transcriptome profiling to reveal gene regulatory network. Examination of Olig2, H327Ac, and H3K4me3 genome-wide occupancy in PDGFB-induced Ctrl-T and Olig2cKO brain tumors (gliomas).

ORGANISM(S): Mus musculus

SUBMITTER: Richard Lu

PROVIDER: E-GEOD-80088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.

Lu Fanghui F Chen Ying Y Zhao Chuntao C Wang Haibo H He Danyang D Xu Lingli L Wang Jincheng J He Xuelian X Deng Yaqi Y Lu Ellen E EE Liu Xue X Verma Ravinder R Bu Hong H Drissi Rachid R Fouladi Maryam M Stemmer-Rachamimov Anat O AO Burns Dennis D Xin Mei M Rubin Joshua B JB Bahassi El Mustapha EM Canoll Peter P Holland Eric C EC Lu Q Richard QR

Cancer cell 20160501 5

Malignant gliomas exhibit extensive heterogeneity and poor prognosis. Here we identify mitotic Olig2-expressing cells as tumor-propagating cells in proneural gliomas, elimination of which blocks tumor initiation and progression. Intriguingly, deletion of Olig2 resulted in tumors that grow, albeit at a decelerated rate. Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis. Olig2 deletion causes a tumor phenot ...[more]

PMID: 27165742

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Chromatin Remodeler CHD7 mutated in CHARGE Syndrome Interacts with Sox10 to Regulate Timing of CNS Myelination and Remyelination.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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