Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mammalian apoptotic factors regulate bacterial gene expression II

ABSTRACT: Mammalian apoptotic factors regulate bacterial gene expression II

PROVIDER: PRJNA737498 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14808602.fastq.gz	Fastqsanger.gz
	SRR14808603.fastq.gz	Fastqsanger.gz
	SRR14808604.fastq.gz	Fastqsanger.gz
	SRR14808605.fastq.gz	Fastqsanger.gz
	SRR14808606.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Mammalian apoptotic factors regulate bacterial gene expression

Project description:Mammalian apoptotic factors regulate bacterial gene expression

| PRJNA734340 | ENA

Mammalian apoptotic factors regulate bacterial gene expression II

Project description:Regulated cell death is an integral part of life, having broad impacts on organism development and homeostasis1. Malfunctions within the regulated cell death process, including the clearance of dying cells, can manifest in diverse pathologies throughout various tissues including the gastrointestinal tract2. A long appreciated, yet elusively defined relationship exists between cell death and gastrointestinal pathologies with an underlying microbial component3–6, but the direct impact of dying mammalian cells on bacterial growth is unclear. Here, we advance a concept that several Enterobacteriaceae, including patient derived clinical isolates, have an efficient growth strategy to exploit soluble factors released from dying gut epithelial cells. Mammalian nutrients released after caspase 3/7 dependent apoptosis boosts the growth of multiple Enterobacteriaceae and is observed using primary mouse colonic tissue, murine and human cell lines, multiple apoptotic triggers, and in conventional as well as germ-free mice in vivo. The mammalian cell death nutrients induce a core transcriptional response in pathogenic Salmonella, and we identify the pyruvate formate lyase encoding pflB gene as a key driver of bacterial colonization in three contexts: a foodborne infection model, a TNF and A20 dependent cell death model, and a chemotherapy induced mucositis model. These findings introduce a new layer to the complex host pathogen interaction, where death induced nutrient release (which we term DINNR) acts as a source of fuel for intestinal bacteria, with implications for gut inflammation and cytotoxic chemotherapy treatment.

2021-08-12 | GSE178167 | GEO

Mammalian apoptotic factors regulate bacterial gene expression

2021-08-12 | GSE175947 | GEO

CETCh-Seq of Mammalian Transcription Factors

Project description:CETCh-Seq of Mammalian Transcription Factors

| PRJNA293987 | ENA

Bacterial transcription factors binding to coding regions regulate the internal cryptic promoters

Project description:Bacterial transcription factors binding to coding regions regulate the internal cryptic promoters

| PRJNA734038 | ENA

Transcription factors interact with RNA to regulate genes

Project description:Transcription factors interact with RNA to regulate genes

| PRJNA971176 | ENA

Splicing and epigenetic factors jointly regulate epidermal differentiation

Project description:Splicing and epigenetic factors jointly regulate epidermal differentiation

| PRJNA471690 | ENA

NFI transcription factors regulate zonal olfactory receptor expression

Project description:NFI transcription factors regulate zonal olfactory receptor expression

| PRJNA666396 | ENA

Artificial acceleration of mammalian cell reprogramming by bacterial proteins

Project description:Mammalian cell reprogramming to pluripotency can be achieved by overexpression of a set of defined transcription factors (Yamanaka factors). Various gene products regulate progression of this process. Some small molecule compounds have been identified to influence it through interacting cellular proteins by library screenings. Although such compounds are useful to reveal mechanisms underlying reprogramming as well as enhancing reprogramming efficiency, the screening usually requires huge amount of compounds to be tested to identify an effective one (ex., one effective molecule in several tens of thousands). Here, we show a case report that there are gene products that can affect efficiency of mammalian cell reprogramming in a xeno-species. Thirty genes specific for a bacterium Wolbachia pipientis, as a pilot trial, were forcedly expressed along with Yamanaka factors in mammalian cells. As a result, we found that 8 Wolbachia genes affected the reprogramming efficiency either positively or negatively. This is a surprisingly high probability compared with small molecule compounds reported. Although this study is just a case report, it shows that screenings using genes from a xenospecies can be so effective. In principle, use of genes from a xenospecies could be useful for controls of various cellular states such as induction or maintenance of a cell type of interest and development novel drugs. Our findings suggest that systems using genes from xeno-species can be novel strategies for a wide variety of cellular events possibly with a high hit rate.

2017-10-19 | GSE96845 | GEO

Neuronal chromatin remodeling factors in the mammalian nervous system

Project description:Neuronal chromatin remodeling factors in the mammalian nervous system

| PRJNA981553 | ENA