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Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer (RNA-Seq)

ABSTRACT: Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer (RNA-Seq)

PROVIDER: PRJNA738937 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14855000.fastq.gz	Fastqsanger.gz
	SRR14855001.fastq.gz	Fastqsanger.gz
	SRR14855002.fastq.gz	Fastqsanger.gz
	SRR14855003.fastq.gz	Fastqsanger.gz
	SRR14855004.fastq.gz	Fastqsanger.gz

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Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer

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Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer (scRNA-Seq)

Project description:Systematically investigating the scores of genes mutated in cancer to discern the real drivers from the inconsequential bystanders is a prerequisite for Precision Medicine but remains challenging. Here, we use CRISPR/Cas9-mediated somatic gene editing in a breast cancer mouse model to assess the transforming potential of 215 recurrent ‘long-tail’ breast cancer genes. Several core and accessory components of the COMPASS-like histone methylase complex, namely KMT2C, KDM6A and ASXL2 cooperated with PIK3CAH1047R mutation to accelerate mammary tumorigenesis in mice and to transform human breast epithelial cells. Mechanistically, mutations of these ‘EpiDrivers’ converged on enhancing the lineage conversion of basal cells to luminal cells prior to tumorigenesis, as well as an aberrant alveolar differentiation program in both luminal and basal cells. Overall, our work suggests that lactation mimicry is associated with the earliest steps of breast cancer.

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2022-09-12 | GSE178422 | GEO

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Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-12 | GSE178424 | GEO

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors

Project description:This SuperSeries is composed of the following subset Series: GSE34892: IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix). GSE34915: IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Illumina). Refer to individual Series

2012-01-07 | E-GEOD-34917 | biostudies-arrayexpress

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

Project description:Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Leif S. Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW,Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee WY, Panse VG, Carr SA, Sankaran VG. Cell 2018, 173, 90–103. https://doi.org/10.1016/j.cell.2018.02.036. Blood cell formation is classically thought to occur through a hierarchical differentiation process, although recent studies have shown that lineage commitment may occur earlier in hematopoietic stem and progenitor cells (HSPCs). The relevance to human blood diseases and the underlying regulation of these refined models remain poorly understood. By studying a genetic blood disorder, Diamond-Blackfan anemia (DBA), where the majority of mutations affect ribosomal proteins and the erythroid lineage is selectively perturbed, we are able to gain mechanistic insight into how lineage commitment is programmed normally and disrupted in disease. We show that in DBA, the pool of available ribosomes is limited, while ribosome composition remains constant. Surprisingly, this global reduction in ribosome levels more profoundly alters translation of a select subset of transcripts. We show how the reduced translation of select transcripts in HSPCs can impair erythroid lineage commitment, illuminating a regulatory role for ribosome levels in cellular differentiation.

2016-10-24 | MSV000080283 | MassIVE

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