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ABSTRACT: Transcriptomic profile of the cockle Cerastoderma edule exposed to Diarrhetic Shellfish Toxins seasonal contamination

PROVIDER: PRJNA739261 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14870539_1.fastq.gz	Fastqsanger.gz
	SRR14870539_2.fastq.gz	Fastqsanger.gz
	SRR14870540_1.fastq.gz	Fastqsanger.gz
	SRR14870540_2.fastq.gz	Fastqsanger.gz
	SRR14870541_1.fastq.gz	Fastqsanger.gz

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Project description:Increased heavy rainfall cause important drops in salinity to values close to 0, which can persist for several days in estuaries. Lethal and sublethal physiological and behavioural effects of decreases in salinity below ten have already been found to occur in the commercially relevant clam species Venerupis corrugata, Ruditapes decussatus and R. philippinarum and the cockle Cerastoderma edule, which generate ~74 million euros annually in Galicia (NW Spain). However, studies of the molecular response to hyposaline stress in bivalves are scarce. This ‘shotgun’ proteomics study evaluates changes in mantle-edge proteins subjected to short-term hyposaline episodes in two different months (March and May) during the gametogenic cycle. We found evidence that the effects of the gametogenic cycle on the proteome are greater than those related to the salinity treatments. However, hyposalinity modulated proteome profiles for both months in V. corrugata and C. edule and on R. philippinarum in May, involving proteins implicated in ROS production, redox homeostasis, cytoskeleton modulation and the activation of apoptotic, autophagic and lipid degradation pathways. Nevertheless, essential proteins for an optimal osmotic stress response but high energy demandants, such as chaperones, osmoprotectants and DNA repair factors, were in both large and small abundance under hyposalinity for those species. In both time points for R. decussatus and R. philippinarum in March, almost no differences between treatments were detected. These exploratory results reinforce the interest in the specific study and conservation of native species C. edule and V. corrugata, particularly sensitive to hyposalinity.

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Project description:Cerastoderma edule RNA-seq data

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Project description:Diarrheic shellfish poisoning (DSP) is caused by the consumption of shellfish contaminated with a group of phycotoxins that includes okadaic acid (OA), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2). These toxins are inhibitors of serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A), but show distinct levels of toxicity. Aside from a difference in PP inhibition potency that would explain these differences in toxicity, others mechanisms of action are thought to be involved. Therefore, we investigated and compared which mechanisms are involved in the toxicity of these three analogues. As the intestine is one of the target organs, we studied the transcriptomic profiles of human intestinal Caco-2 cells exposed to OA, DTX-1, and DTX-2. The pathways specifically affected by each toxin treatment were further confirmed through the expression of key genes and markers of toxicity. Our results did not identify any distinct biological mechanism for OA and DTX-2. However, only DTX-1 induced up-regulation of the MAPK transduction signalling pathway, and down-regulation of gene products involved in the regulation of DNA repair. As a consequence, based on transcriptomic results, we demonstrated that the higher toxicity of DTX-1 compared to OA and DTX-2 was consistent with certain specific pathways involved in intestinal cell response.

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Project description:Unravelling epigenetic mechanisms in Cerastoderma edule genome: A comparison of healthy and neoplastic cockles

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