Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bartonella australis Aust/NH1

ABSTRACT: Bartonella australis Aust/NH1 Genome sequencing

PROVIDER: PRJNA73943 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR351405.fastq.gz	Fastqsanger.gz
	SRR351412.fastq.gz	Fastqsanger.gz
	SRR351412_1.fastq.gz	Fastqsanger.gz
	SRR351412_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Bartonella australis

Project description:Bartonella australis overview

| PRJNA76171 | ENA

Bartonella australis Aust/NH1

Project description:Testing the reproducibility of multiple displacement amplification on genomes of clonal endosymbiont populations

| PRJNA222516 | ENA

Comparative genomic hybridization of Bartonella koehlerae and Bartonella quintana with Bartonella henselae

Project description:Comparative genome hybridizations (CGH) of Bartonella koehlerae and Bartonella quintana to a Bartonella henselae microarray.

2005-07-01 | E-MEXP-331 | biostudies-arrayexpress

Subversion of host innate immunity by Rickettsia australis via a modified autophagic response in macrophages

Project description:We recently reported that the in vitro and in vivo survival of Rickettsia australis are Atg5-dependent, in association with an inhibited level of anti-rickettsial cytokine, IL-1β. In the present study, we sought to investigate how R. australis interacts with host innate immunity via an Atg5-dependent autophagic response. We found that the serum levels of IFN-γ and G-CSF in R. australis-infected Atg5flox/floxLyz-Cre mice were significantly less compared to Atg5flox/flox mice, accompanied by significantly lower rickettsial loads in tissues with inflammatory cellular infiltrations including neutrophils. R. australis infection differentially regulated a significant number of genes in bone marrow-derived macrophages (BMMs) in an Atg5-depdent fashion as determined by RNA sequencing and Ingenuity Pathway Analysis, including genes in the molecular networks of IL-1 family cytokines and PI3K-Akt-mTOR. The secretion levels of inflammatory cytokines, such as IL-1α, IL-18, TNF-α, and IL-6, by R. australis-infected Atg5flox/floxLyz-Cre BMMs were significantly greater compared to infected Atg5flox/flox BMMs. Interestingly, R. australis significantly increased the levels of phosphorylated mTOR and P70S6K at a time when the autophagic response is induced. Rapamycin treatment nearly abolished the phosphorylated mTOR and P70S6K but did not promote significant autophagic flux during R. australis infection. These results highlight that R. australis modulates an Atg5-dependent autophagic response, which is not sensitive to regulation by mTORC1 signaling in macrophages. Overall, we demonstrate that R. australis counteracts host innate immunity including IL-1β-dependent inflammatory response to support the bacterial survival via an mTORC1-resistant autophagic response in macrophages.

2021-04-06 | GSE171160 | GEO

Bartonella quintana: growth phase and temperature response

Project description:Transcriptional profiling of Bartonella quintana grown on a plate at 28C and 37C for various time points.

2012-12-05 | GSE42685 | GEO

Nocardia mangyaensis strain:NH1

Project description:Nocardia mangyaensis strain:NH1 Genome sequencing and assembly

| PRJNA995426 | ENA

Algoriphagus resistens strain:NH1

Project description:Algoriphagus resistens strain:NH1 Genome sequencing and assembly

| PRJNA301083 | ENA

Fusarium solani strain:NK-NH1

Project description:Fusarium solani strain:NK-NH1 Genome sequencing and assembly