Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA739726 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR14872549_1.fastq.gz | Fastqsanger.gz | |||
| SRR14872549_2.fastq.gz | Fastqsanger.gz | |||
| SRR14872550_1.fastq.gz | Fastqsanger.gz | |||
| SRR14872550_2.fastq.gz | Fastqsanger.gz | |||
| SRR14872551_1.fastq.gz | Fastqsanger.gz |
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Project description:Epithelial Barrier and Leaky Gut in Dyspepsia Running title: Epithelial Barrier and Leaky Gut in Dyspepsia Context: Some studies suggest that FD is associated with ex vivo duodenal epithelial micro-inflammation and barrier impairment; the pathogenesis of these findings is unclear. miRNAs reduce expression of epithelial barrier genes and have been postulated to increase epithelial permeability in irritable bowel syndrome. New findings: Compared to controls, there is reduced mRNA expression of several barrier proteins (zona occludin-1), increased expression of several miRNAs (eg, miR-142-3p) that suppress the genes for barrier proteins in FD. However, mucosal eosinophils, intraepithelial lymphocytes, and mast cells, ex- and in vivo permeability (urinary lactulose and mannitol excretion) were not significantly different in FD. Impact: Patients with FD do not have a leaky gut syndrome.
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