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Human prostate luminal epithelia adopt a club-like state in response to low androgen levels

ABSTRACT: Human prostate luminal epithelia adopt a club-like state in response to low androgen levels

PROVIDER: PRJNA741514 | ENA |

REPOSITORIES: ENA

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Human prostate luminal epithelia adopt a club-like state in response to low androgen levels (spatial and single-cell transcriptomics)

Project description:Human prostate luminal epithelia adopt a club-like state in response to low androgen levels (spatial and single-cell transcriptomics)

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Human prostate luminal epithelia adopt a club-like state in response to low androgen levels (spatial and single-cell transcriptomics)

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Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

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Project description:Gene expression patterns of bronchiolar progenitors and club cells in mouse lung were examined by microarray experiments. Although it has not yet been fully characterized, a subset of epithelial cells lining bronchioles are best understood as bronchiolar progenitors that self-renew over the long term and that can differentiate into more differentiated club cells and ciliated cells. The bronchiolar progenitors are distinct from club cells and characteristically express the alveolar type 2 cell marker, prosurfactant protein C, with lower levels of club cell secretory protein/Scgb1a1. There are also functional differences between them; while club cells can be depleted by naphthalene because of the abundance of cytochrome P450 enzyme Cyp2f2, bronchiolar progenitors are resistant to naphthalene-induced depletion because of defects in the enzyme.

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