Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain [array]

ABSTRACT: A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain [array]

PROVIDER: PRJNA743514 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

LSD influences gene expression patterns within the mammalian brain

Project description:LSD influences gene expression patterns within the mammalian brain

| PRJNA743512 | ENA

A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain [array]

Project description:We have undertaken the first comprehensive analysis of gene expression influenced by acute LSD administration in the mammalian brain to elucidate the mechanism of action of this class of drugs. We have identified a number of genes that are predicted to be involved in the processes of synaptic plasticity, glutamatergic signaling and cytoskeletal architecture. Understanding these molecular events will lead to new insights into the etiology of disorders whose behavioral symptoms resemble the temporary effects of hallucinogenic drugs, and also may ultimately result in new therapies.

2021-11-11 | GSE179378 | GEO

LSD influences gene expression patterns within the mammalian brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-11-11 | GSE179380 | GEO

CDX2 dose-dependently influences the GRN underlying vascularization in human extraembryonic mesoderm-like cells

Project description:CDX2 dose-dependently influences the GRN underlying vascularization in human extraembryonic mesoderm-like cells

| PRJNA1055491 | ENA

CDX2 dose-dependently influences the GRN underlying vascularization in human extraembryonic mesoderm-like cells

Project description:Proper regulation of gene dosage is critical for the development of the early embryo and the extraembryonic tissues that support it. Specifically, loss of Cdx2 in vivo leads to stunted development of the allantois, an extraembryonic mesoderm-derived structure that is critical for nutrient delivery and waste removal in the early embryo. In this study, we investigate how CDX2 dose-dependently influences the gene regulatory network underlying extraembryonic mesoderm development. By generating an allelic series for CDX2 in human induced pluripotent stem cells consisting of WT, heterozygous, and null CDX2 genotypes, differentiating these cells in a 2D gastruloid model, and subjecting these cells to multiomic single nucleus RNA and ATAC sequencing, we identify several genes regulating cytoskeletal integrity, adhesiveness, and polarity of the extraembryonic mesoderm and in a dose-dependent manner, including CDH1 and WNT5B. Despite these dose-dependent gene expression patterns, snATAC-seq reveals that heterozygous CDX2 expression is capable of inducing a WT-like chromatin accessibility profile, suggesting accessibility is not sufficient to drive gene expression when the CDX2 dose is reduced. Finally, because the loss of CDX2 or TBXT phenocopy one another in vivo, we compare differentially expressed genes in our CDX2 knock-out model to those from TBXT knock-out hiPSCs differentiated in an analogous experiment. This comparison identifies several genes critical for cytoskeletal integrity and vasculogenesis, including ANK3 and ANGPT1. Taken together, these results inform how CDX2 dose-dependently regulates gene expression in the extraembryonic mesoderm and suggest these genes may underlie defects in vascular development and allantoic elongation seen in the absence or reduction of CDX2 in vivo.

2024-02-14 | GSE251813 | GEO

Host derivation of Sindbis virus influences mammalian type 1 interferon response to infection

Project description:Host derivation of Sindbis virus influences mammalian type 1 interferon response to infection

| PRJNA981096 | ENA

Single-cell transcriptomic analysis unveils the diversity within mammalian spinal motor neurons

Project description:Single-cell transcriptomic analysis unveils the diversity within mammalian spinal motor neurons

| PRJNA761994 | ENA

Adiponectin in the mammalian host influences ticks' acquisition of the Lyme disease pathogen Borrelia

Project description:Adiponectin in the mammalian host influences ticks' acquisition of the Lyme disease pathogen Borrelia

| PRJNA977243 | ENA

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

Project description:A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

| PRJNA702926 | ENA

Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host

Project description:The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM-^@M-^Xslender formsM-bM-^@M-^Y to transmissible M-bM-^@M-^Xstumpy formsM-bM-^@M-^Y through morphological intermediates. This transition is temporally progressive within the first wave of parasitaemia such that gene expression can be monitored in relatively pure slender and stumpy populations as well as during the progression between these extremes. The development also represents the progression of cells from translationally active forms adapted for proliferation in the host to translationally quiescent forms, adapted for transmission. We have used metabolic labelling to quantitate translational activity in slender forms, stumpy forms and in forms undergoing early differentiation to procyclic forms in vitro. Thereafter we have examined the cohort of total mRNAs that are enriched in throughout development in the mammalian bloodstream (slender, intermediate and stumpy forms), irrespective of strain, revealing those that exhibit consistent developmental regulation rather than sample specific changes. Transcripts that cosediment with polysomes in stumpy forms and slender forms have also been identified to enrich transcripts that escape translational repression prior to transmission. Combined, the expression and polysomal association of transcripts as trypanosomes undergo development in the mammalian bloodstream haves been defined, providing a resource for trypanosome researchers. This facilitates the identification of those that undergo developmental regulation in the bloodstream and therefore those likely to have a role in the survival and capacity for transmission of stumpy forms. Examination of gene expression during life cycle stages.

2013-12-16 | E-GEOD-46388 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data