Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus strain:C57BL/6J

ABSTRACT: Whole genome bisulfite sequencing (WGBS) analysis of murine splenic DC subtypes

PROVIDER: PRJNA748535 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15239537_1.fastq.gz	Fastqsanger.gz
	SRR15239537_2.fastq.gz	Fastqsanger.gz
	SRR15239538_1.fastq.gz	Fastqsanger.gz
	SRR15239538_2.fastq.gz	Fastqsanger.gz
	SRR15239539_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Characterization of the DNA methylome in retinal pigment epithelium (RPE) of adult mice

Project description:We investigated the epigenetic plasticity of adult murine RPE using whole-genome bisulfite sequencing (WGBS)

2019-03-19 | GSE120591 | GEO

Characterization of the DNA methylome in murine Müller glia

Project description:We investigated the epigenetic plasticity of adult (postnatal day (P) 28) murine Müller glia using whole-genome bisulfite sequencing (WGBS)

2019-07-23 | GSE122356 | GEO

Characterizing phenotypic data of Peromyscus leucopus compared to C57BL/6J Mus musculus and diversity outbred (DO) Mus musculus.

Project description:Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we evaluate the suitability of the white-footed deer mouse (Peromyscus leucopus) as a model organism for aging research, offering a comparative analysis against C57B6/J and diversity outbred (DO) Mus musculus strains. Our study includes comparisons of body composition, skeletal muscle function, and cardiovascular parameters, shedding light on potential applications and limitations of P. leucopus in aging studies. Notably, P. leucopus exhibits distinct body composition characteristics, emphasizing reduced muscle force exertion and a unique metabolism, particularly in fat mass. Cardiovascular assessments showed changes in arterial stiffness, challenging conventional assumptions and highlighting the need for a nuanced interpretation of aging-related phenotypes. Our study also highlights inherent challenges associated with maintaining and phenotyping P. leucopus cohorts. Behavioral considerations, including anxiety-induced responses during handling and phenotyping assessment, pose obstacles in acquiring meaningful data. Moreover, the unique anatomy of P. leucopus necessitates careful adaptation of protocols designed for Mus musculus. While showcasing potential benefits, further extensive analyses across broader age ranges and larger cohorts are necessary to establish the reliability of P. leucopus as a robust and translatable model for aging studies.

| S-EPMC11335981 | biostudies-literature

Project description: Not available

| S-EPMC6924556 | biostudies-literature

DNA methylome analysis of pediatric acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands.

Project description:We used whole genome bisulfite sequencing (WGBS) to determine the DNA methylation levels at single base-pair resolution of four patients with different subtypes of pediatric ALL together with RNA-sequencing to increase our understanding of the leukemic transformation in ALL.

2016-10-31 | GSE76270 | GEO

Expression data from C57BL/6 wild type and MK2-deleted lipopolysaccharide (LPS)-activated murine splenic dendritic cells

Project description:Upon toll-like receptor (TLR) ligation, dendritic cells (DCs) undergo an activation process referred to as maturation. Over the course of maturation, global DC gene expression is severely altered, resulting in phenotypic changes including DC morphology, migration, immune stimulatory and inhibitory receptor expression, cytokine production, etc. We performed microarray analysis to investigate changes in gene expression patterns between wild type and MK2-deleted murine splenic DCs over time (0 - 24 hours) following TLR stimulation by LPS.

2017-11-01 | GSE96628 | GEO

Mus musculus strain:C57BL/6J

Project description:Murine hind limb sc-RNA seq

| PRJNA792884 | ENA

Bisulfite sequencing of medaka egg methylomes

Project description:Medaka egg methylomes were sequenced using whole genome bisulfite sequencing (WGBS)

2024-11-01 | GSE160094 | GEO

Bisulfite sequencing of medaka PGCs methylomes

Project description:Medaka PGCs methylomes were sequenced using whole genome bisulfite sequencing (WGBS)

2019-12-25 | GSE130002 | GEO

Bisulfite sequencing of medaka sperm methylomes

Project description:Medaka sperm methylomes were sequenced using whole genome bisulfite sequencing (WGBS)