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RNA-seq of H1299 overexpressing GFP(control) and SALL4

ABSTRACT: RNA-seq of H1299 overexpressing GFP(control) and SALL4

PROVIDER: PRJNA748768 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR15210494_1.fastq.gz	Fastqsanger.gz
	SRR15210494_2.fastq.gz	Fastqsanger.gz
	SRR15210495_1.fastq.gz	Fastqsanger.gz
	SRR15210495_2.fastq.gz	Fastqsanger.gz
	SRR15210496_1.fastq.gz	Fastqsanger.gz

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RNA-seq of H1299 overexpressing GFP(control) and SALL4

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Project description:Transcription factors are important drivers of cancer but the development of therapeutics against these factors has had limited success. We developed a stringent high-throughput chemical genetic screening platform to identify compounds that target oncogene SALL4 dependency in liver cancer. The platform comprises SALL4 low- and high-expressing endogenous cell lines, and engineered SALL4-low isogenic lines overexpressing SALL4. We identified 4 oxidative phosphorylation (OXPHOS) inhibitors, from screening 21,575 natural product extracts, that selectively reduce SALL4-dependent cell viability. ATP synthase inhibitor Oligomycin suppresses SALL4-expressing cancer in culture and in vivo. When aberrantly overexpressed in cancer, SALL4 binds ~50% of OXPHOS and other mitochondrial genes, upregulating their expression. SALL4 upregulation also functionally increases OXPHOS. Our endogenous/isogenic transcription factor-screening platform reveals a therapeutically actionable OXPHOS vulnerability in SALL4-expressing cancer.

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