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CHIP-Seq analysis of CREB1 binding after ALVAC vaccination in Human PBMC

ABSTRACT: CHIP-Seq analysis of CREB1 binding after ALVAC vaccination in Human PBMC

PROVIDER: PRJNA749319 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15234348.fastq.gz	Fastqsanger.gz
	SRR15234349.fastq.gz	Fastqsanger.gz
	SRR15234350.fastq.gz	Fastqsanger.gz
	SRR15234351.fastq.gz	Fastqsanger.gz
	SRR15234352.fastq.gz	Fastqsanger.gz

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CHIP-Seq analysis of CREB1 binding after ALVAC vaccination in Human PBMC

Project description:The RV144 HIV vaccine trial remains the only study to demonstrate significant protection from future HIV-1 acquisition. One of the key components of the RV144 vaccine was the use of the canarypox vector ALVAC as the priming component. Since AIDSVAX, the booster component, alone failed to provide protection we hypothesized that the ALVAC prime contributed significantly to the generation of protection. To test this, we designed a NHP immunogenicity trial to mechanistically link ALVAC vaccination with the magnitude of V1V2 titers, the most significant immune correlate of reduced HIV-1 acquisition in RV144. Our objective was to use a systems biology approach to identify the transcription factors, target genes and immune pathways which were being induced by ALVAC vaccination and associated with higher V1V2 titers. We identified the transcription factor CREB1 and its target genes as rapidly induced by ALVAC in multiple immune subsets and that CREB1 drives the expression and activation of a network of other TFs which are critical for modulating immune responses. Pathways induced by this ALVAC-CREB1 axis include lymphocyte/leukocyte migration, lymphocyte differentiation, antigen processing and presentation, T cell co-stimulation and cytokine signaling.

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CHIP-Seq analysis of CREB1 binding after ALVAC vaccination

Project description:CHIP-Seq analysis of CREB1 binding after ALVAC vaccination

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CHIP-Seq analysis of CREB1 binding after ALVAC vaccination in NHP

Project description:CHIP-Seq analysis of CREB1 binding after ALVAC vaccination in NHP

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Project description:ALVAC-Comp was an NHP immunogenicity study designed to identify the temporal kinetics of innate immune activation by ALVAC-SIV vaccination. PAXGENE tubes were harvested at 16h, 24h, 48h and 72h post vaccination to investigate the speed, magnitude, and durability of ALVAC-SIV induced innate immune activation. This study was set up to identify the optimal timepoint(s) post-vaccination in which to probe the cellular and molecular signaling mechanisms of innate immunity induced by vaccination. Comparison of genes/pathways in common and unique to the 4 post-vaccination timepoints will reveal the order of innate immune induction post-vaccination.

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CHIP-Seq analysis of CREB1 binding after ALVAC vaccination

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