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MEOX2 homeobox gene promotes growth of malignant gliomas

ABSTRACT: MEOX2 homeobox gene promotes growth of malignant gliomas

PROVIDER: PRJNA750780 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15300634.fastq.gz	Fastqsanger.gz
	SRR15300635.fastq.gz	Fastqsanger.gz
	SRR15300636.fastq.gz	Fastqsanger.gz
	SRR15300637.fastq.gz	Fastqsanger.gz
	SRR15300638.fastq.gz	Fastqsanger.gz

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MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

Project description:Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated RTK signaling pathways. Here, we identify mesenchymal homeobox 2 (MEOX2) as a salient oncogenic transcription factor candidate with increased expression in GBMs. Our results suggest that MEOX2 can enhance ERK signaling through a feed-forward mechanism. We show that MEOX2 overexpression can lead to increased growth in bona fide GBM implantation models and cooperates with loss of p53 and PTEN in cerebral organoid models of human malignant gliomas to induce cell proliferation. Furthermore, using high-throughput genomics, we identify transcriptional target genes of MEOX2 in patient-derived GBM tumorsphere models and a fresh frozen GBM tumor.

2022-07-01 | GSE181144 | GEO

MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

2022-07-01 | GSE181145 | GEO

MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

Project description:MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

| PRJNA750790 | ENA

MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

Project description:MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

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MEOX2 homeobox gene promotes growth of malignant gliomas

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-01 | GSE181146 | GEO

MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma.

Project description:Nuclear transcription factor Mesenchyme Homeobox 2 (MEOX2) is a homeobox gene that is originally discovered to suppress the growth of vascular smooth muscle and endothelial cells. However, whether or not it is connected to cancer is yet unknown. Here, we report that MEOX2 functions as a tumor-initiating element in glioma. Bioinformatic analyses of public databases and investigation of MEOX2 expression in patients with glioma demonstrated that MEOX2 was abundant at both mRNA and protein levels in glioma. MEOX2 expression was shown to be inversely linked with the prognosis of glioma patients. MEOX2 inhibition changed the morphology of glioma cells, inhibited cell proliferation and motility, whereas had no effect on cell apoptosis. Besides, silencing of MEOX2 also hampered the epithelial-mesenchymal transition (EMT), focal adhesion maturation, and F-actin assembly. Overexpression of MEOX2 exhibited opposite effects. Importantly, RNA-seq, ChIP assay, and luciferase reporter assay revealed Cathepsin S (CTSS) as a novel transcriptional target of MEOX2 in glioma cells. Consistently, MEOX2 causes glioma tumor development in mice and greatly lowers the survival period of tumor-bearing mice. Our findings indicate that MEOX2 promotes tumorigenesis and progression of glioma partially through the regulation of CTSS. Targeting the MEOX2-CTSS axis might be a promising alternative for the treatment of glioma.

2022-04-01 | GSE197758 | GEO

GNPS - Metabolic detection of malignant brain gliomas through lipidomic analysis

Project description:Lipidomic analysis of malignant brain gliomas to search for biomarkers.

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Enterovirus 71 oncolysis of malignant gliomas

Project description:This study finds that EV71 has oncolytic activity against experimental human malignant gliomas. RNA-seq analysis of infected glioma cells reveals transcriptional up-regulation, notably genes in apoptosis pathways. Application of virus targeting based on brain-specific microRNA-124 enhances the safety profile. Oncolysis with EV71 may be a potentially novel treatment for malignant gliomas.

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Project description:Enterovirus 71 oncolysis of malignant gliomas

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MEOX2 Regulates Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through PI3K/AKT Signaling Pathway

Project description:The fat tail of sheep is an important organ that has evolved to adapt to extreme environmental conditions. Mesenchyme homeobox 2 (MEOX2) can inhibit adipogenic differentiation of stromal vascular fractions (SVFs) isolated from ovine tail adipose tissue. However, the underlying mechanism through which MEOX2 regulates ovine adipogenesis remains unclear. Therefore, this study aims to employ RNA sequencing (RNA-seq) to explore the downstream genes regulated by MEOX2 during the adipogenic differentiation of ovine SVFs. Based on RNA sequencing, several differentially expressed genes (DEGs) were identified in response to MEOX2 overexpression. The PI3K/AKT signaling pathway was significantly enriched in DEGs, indicating its importance in mediating fat accumulation regulated by MEOX2. Additionally, the PI3K/AKT signaling pathway activation was found to be crucial for ovine SVF adipogenic differentiation. Mechanistically, MEOX2 inhibited the PI3K/AKT pathway. These findings highlight the significance of the PI3K/AKT signaling pathway during ovine SVF adipogenic differentiation. Furthermore, they shed light on the involvement of MEOX2 in this differentiation via the PI3K/AKT pathway. Our findings provide novel insights into the critical role of MEOX2 as an adipogenetic differentiation regulator, potentially enhancing our understanding of ovine fat development and its regulatory processes.

2024-10-01 | GSE266851 | GEO

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