Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of differential gene expression profile in rats showing risk-averse and risk-seeking preferences in rat gambling task (rGT)

ABSTRACT: Identification of differential gene expression profile in rats showing risk-averse and risk-seeking preferences in rat gambling task (rGT)

PROVIDER: PRJNA751499 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15323800_1.fastq.gz	Fastqsanger.gz
	SRR15323800_2.fastq.gz	Fastqsanger.gz
	SRR15323801_1.fastq.gz	Fastqsanger.gz
	SRR15323801_2.fastq.gz	Fastqsanger.gz
	SRR15323802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

Identification of differential gene expression profile in rats showing risk-averse and risk-seeking preferences in rat gambling task (rGT)

Project description:In the present study, we examined using next-generation sequencing (NGS) whether there are differences in gene expression profiles in the brain when rats make different choices toward risk in rGT.

2022-09-14 | GSE181296 | GEO

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.

Project description:Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment. A growing body of research has detailed the important connections between the brain and the resident population of bacteria in the gut, the gut microbiome in psychiatric disease models. Acute depletion of gut bacteria results in enhanced reward in a mouse cocaine place preference model, and repletion of bacterially-derived short-chain fatty acid (SCFA) metabolites reverses this effect. However, the role of the gut microbiome and its metabolites in modulating cocaine-seeking behavior after prolonged abstinence is unknown. Given that relapse prevention is the most clinically challenging issue in treating substance use disorders, studies examining the effects of microbiome manipulations in relapse-relevant models are critical. Here, Sprague-Dawley rats received either untreated water or antibiotics to deplete the gut microbiome and its metabolites. Rats were trained to self-administer cocaine and subjected to either within-session threshold testing to evaluate motivation for cocaine or 21 days of abstinence followed by a cue-induced cocaine-seeking task to model relapse behavior. Microbiome depletion did not affect cocaine acquisition on an FR1 schedule. However, microbiome-depleted subjects exhibited significantly enhanced motivation for low dose cocaine on a within-session threshold task. Similarly, microbiome depletion increased cue-induced cocaine-seeking following prolonged abstinence. In the absence of a normal microbiome, repletion of bacterially-derived SCFA metabolites reversed the behavioral and transcriptional changes associated with microbiome depletion. These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target.

2024-05-01 | GSE227980 | GEO

Solar exposed skin induces sex-dependent food-seeking behavior

Project description:Considering the distinct physiologies of men and women, it stands to reason that they would react differently to solar exposure, but such a study was never conducted before. Here we show that solar exposure induces food-seeking behavior, food intake and weight gain in males, but not in females, by epidemiological analysis, blood-serum proteomics, UVB-exposed mouse behavioral models and human cohort questionnaires . The underlying mechanism entails increased ghrelin secretion from skin adipocytes into the circulation. UVB irradiation led to p53 transcriptional activation of ghrelin in skin adipocytes, with mouse conditional p53-knockout abolishing UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promotor, thus blocking ghrelin and, consequently, food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of human physiology in furless animals and may lead to therapeutic opportunities for sex-based treatment of endocrine-related diseases.

2022-06-23 | PXD033203 | Pride

Multi-task learning uncovers robust translation cis-regulatory features

Project description:To validate the sequence motifs identified by our multi-task learning model MTtrans, a new 5' UTR library with around 8,000 synthetic 5'UTRs was built to express EGFP. The reads count was used as a proxy of translation rate here to validate the estimated regulatory effect of motifs that we inferred from multiple datasets, proving the robustness of the sequence motifs.

2022-04-28 | GSE201766 | GEO

Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET)

Project description:Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET)

| PRJNA341430 | ENA

Transcription factor-SNP interactome for colorectal cancer risk loci

Project description:A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF binding to 10 putatively functional SNPs. Our data further revealed TF binding complexity adjacent to the 116 risk loci, adding an additional layer of understanding to regulatory networks associated with CRC relevant loci.

2017-02-23 | PXD004435 | Pride

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.

Project description:Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.

| PRJNA947613 | ENA

Transcription profiling of hippocampi from scopolamine treated adult rats following stimulation in a spatial memory task

Project description:Hippocampal gene expression profiling in scopolamine treated adult rats following stimulation in a spatial memory task

2006-12-30 | E-MEXP-920 | biostudies-arrayexpress

Comprehensive profiling of Roquin binding preferences for RNA stem-loops

Project description:Roquin proteins target specific RNA stem-loop motifs with their unique ROQ domain for mRNA degradation. The cellular levels of mRNAs are controlled by these post-transcriptional cis-regulatory stem-loop elements in the 3'-untranslated region (3'-UTR). Here, we first provide an RBNS (RNA Bind-n-Seq) experiment using pre-structured RNA libraries as input. This sRBNS (structured RBNS) was used to map Roquin's RNA binding preferences at nucleotide resolution, revealing preferences for loop sizes and consensus motifs for CDEs and ADEs.

2024-10-03 | GSE270841 | GEO

Two-motif model illuminates DICER cleavage preferences

Project description:Two-motif model illuminates DICER cleavage preferences

| PRJNA1036236 | ENA