Project description:<p>SNP Health Association Resource (SHARe) Asthma Resource project (SHARP) is conducting a genome-wide analysis in adults and children
who have participated in National Heart, Lung, and Blood Institute's clinical research trials on asthma. This includes 1041 children
with asthma who participated in the Childhood Asthma Management Program (CAMP), 994 children who participated in one or five clinical
trials conducted by the Childhood Asthma Research and Education (CARE) network, and 701 adults who participated in one of six clinical
trials conducted by the Asthma Clinical Research Network (ACRN).</p>
<p>There are three study types. The longitudinal clinical trials can be subsetted for population-based and/or case-control analyses.
Each of the childhood asthma studies has a majority of children participating as part of a parent-child trio. The ACRN (adult)
studies are probands alone. Control genotypes will be provided for case-control analyses.</p>
Project description:<p>SNP Health Association Resource (SHARe) Asthma Resource project (SHARP) is conducting a genome-wide analysis in adults and children
who have participated in National Heart, Lung, and Blood Institute's clinical research trials on asthma. This includes 1041 children
with asthma who participated in the Childhood Asthma Management Program (CAMP), 994 children who participated in one or five clinical
trials conducted by the Childhood Asthma Research and Education (CARE) network, and 701 adults who participated in one of six clinical
trials conducted by the Asthma Clinical Research Network (ACRN).</p>
<p>There are three study types. The longitudinal clinical trials can be subsetted for population-based and/or case-control analyses.
Each of the childhood asthma studies has a majority of children participating as part of a parent-child trio. The ACRN (adult)
studies are probands alone. Control genotypes will be provided for case-control analyses.</p>
Project description:The IL-13 is a central mediator of allergic asthma. This project investigates the mechanisms by which IL-13 elicits the symptoms of asthma. Keywords: other
Project description:A growing body of single-cell multi-omic tools enables a better understanding of gene regulation underlying development and disease. Tools mapping chromatin and gene expression (such as SHARE-seq) are limited in sensitivity and scalability. Here, we describe SHARE-seqV2 and its associated cloud-computing resource, enabling single-cell analysis at improved quality, robustness, and scale. We apply SHARE-seqV2 across various cell lines, primary tissues, and immune cells, demonstrating a generalizable platform for single-cell multi-omics.
