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SETDB1-TRIM28 complex suppresses antitumor immunity [RNA-seq]

ABSTRACT: SETDB1-TRIM28 complex suppresses antitumor immunity [RNA-seq]

PROVIDER: PRJNA754434 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15446577_1.fastq.gz	Fastqsanger.gz
	SRR15446577_2.fastq.gz	Fastqsanger.gz
	SRR15446578_1.fastq.gz	Fastqsanger.gz
	SRR15446578_2.fastq.gz	Fastqsanger.gz
	SRR15446579_1.fastq.gz	Fastqsanger.gz

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SETDB1-TRIM28 complex suppresses antitumor immunity

Project description:SETDB1-TRIM28 complex suppresses antitumor immunity

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SETDB1-TRIM28 complex suppresses antitumor immunity [RNA-seq]

Project description:Epigenetic mechanism contributes to immune landscapes in cancer. Here we identify the SETDB1-TRIM28 complex as a critical suppressor of antitumor immunity. An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a novel suppressor of PD-L1 expression. We revealed that expression of the SETDB1-TRIM28 complex negatively correlates with infiltration of effector CD8+ T cells. Inhibition of SETDB1-TRIM28 simultaneously upregulates PD-L1 and activates the cGAS-STING innate immune response to increase infiltration of CD8+ T cells. Mechanistically, SETDB1-TRIM28 inhibition leads to micronuclei formation in cytoplasm, a known activator of the cGAS-STING pathway. Thus, SETDB1-TRIM28 inhibition bridges the innate and adaptive immunity. Indeed, SETDB1 knockout enhances the antitumor effects of immune checkpoint blockade anti-PD-L1 in an ovarian cancer mouse model in a cGAS dependent manner. Our findings establish SETDB1-TRIM28 complex as a regulator of antitumor immunity and its loss activates cGAS-STING innate immunity to boost antitumor effects of immune checkpoint blockades.

2021-10-20 | GSE182089 | GEO

SETDB1-TRIM28 complex suppresses antitumor immunity [CRISPR/Cas9 screen]

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SETDB1-TRIM28 complex suppresses antitumor immunity [CRISPR/Cas9 screen]

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SETDB1-TRIM28 complex suppresses antitumor immunity

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2021-10-20 | GSE182198 | GEO

Dnase1l3 enhances antitumor immunity and suppresses tumor progression

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Dnase1l3 enhances antitumor immunity and suppresses tumor progression [scRNAseq]

Project description:Dnase1l3 enhances antitumor immunity and suppresses tumor progression [scRNAseq]

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Dnase1l3 enhances antitumor immunity and suppresses tumor progression [bulk RNAseq]

Project description:Dnase1l3 enhances antitumor immunity and suppresses tumor progression [bulk RNAseq]

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Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

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LARP7 suppresses endothelial-to-mesenchymal transition by coupling with TRIM28

Project description:LARP7 plays a pivotal role in regulating endothelial-to-mesenchymal transition(EndMT) and EndMT-associated heart valve formation. LARP7 directly interactes with TRIM28 and cooperatively represses SLUG transcription, which thereby suppresses EndMT of endothelial cells. More importantly, inducible knockout of LARP7 or TRIM28 in the endocardium promotes EndMT in vivo and leads to the valvular hyperplasia.

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