Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Distinct stage-specific transcriptional states of B cells in human tonsillar tissue [single-cell RNA-seq]

ABSTRACT: Distinct stage-specific transcriptional states of B cells in human tonsillar tissue [single-cell RNA-seq]

PROVIDER: PRJNA755326 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15488018.fastq.gz	Fastqsanger.gz
	SRR15488019.fastq.gz	Fastqsanger.gz
	SRR15488020.fastq.gz	Fastqsanger.gz
	SRR15488021.fastq.gz	Fastqsanger.gz
	SRR15488022.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Distinct stage-specific transcriptional states of B cells in human tonsillar tissue [single-cell RNA-seq]

Project description:Defining B cell states in human tonsillar tissue using single cell transcriptomics.

2021-08-16 | GSE182221 | GEO

Distinct stage-specific transcriptional states of B cells derived from human tonsillar tissue.

Project description:B cells within secondary lymphoid tissues encompass a diversity of activation states and multiple maturation processes that reflect antigen recognition and transition through the germinal center (GC) reaction, in which mature B cells differentiate into memory and antibody-secreting cells (ASCs). Here, utilizing single-cell RNA-seq, we identify a range of distinct activation and maturation states of tonsil-derived B cells. In particular, we identify what we believe is a previously uncharacterized CCL4/CCL3 chemokine-expressing B cell population with an expression pattern consistent with B cell receptor/CD40 activation. Furthermore, we present a computational method that leverages regulatory network inference and pseudotemporal modeling to identify upstream transcription factor modulation along a GC-to-ASC axis of transcriptional maturation. Our data set provides valuable insight into diverse B cell functional profiles and will be a useful resource for further studies into the B cell immune compartment.

| S-EPMC10132144 | biostudies-literature

lung and tonsillar mast cells

Project description:GeneChip Data of human lung mast cells and tonsillar mast cells Keywords: other

2004-10-20 | GSE1848 | GEO

Transcriptomic analysis of human tonsillar TFH subsets

Project description:We used an IL4-capture assay followed by FACS sorting, to isolate IL4-secreting TFH cells from a human tonsil and compared their transcriptomic profiles with CXCR5hi PD1hi IL4-negative tonsillar TFH cells and IL4-producing CXCR5neg non-TFH cells (TH2 cells). Our studies validate the notion of functionally distinct TFH subsets and identify genes that are specifically expressed in and define the human IL-4 secreting TFH cell subset.

2018-04-03 | GSE111968 | GEO

Transcription profiling of human lung and tonsillar mast cells

Project description:GeneChip Data of human lung mast cells and tonsillar mast cells

2008-06-11 | E-GEOD-1848 | biostudies-arrayexpress

Gene expression profile at single cell level of tumor infiltrating myeloid antigen presenting cells from tonsillar cancer patients

Project description:Myeloid antigen presenting cells are a heterogeneous population, and their identity is greatly influenced by niche specific cues. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of myeloid antigen presenting cells in tonsillar cancer tissue and paired contralateral healthy tissue.

2023-01-19 | GSE219210 | GEO

Organ-specific tissue-resident macrophages dynamics during blood stage malaria

Project description:Organ-specific tissue-resident macrophages dynamics during blood stage malaria

| PRJNA476465 | ENA

Sex-, stage-, and tissue-specific alternative splicing in Drosophila melanogaster

Project description:We used long-oligonucleotide microarrays to investigate whether alternative splicing in Drosophila is regulated in a sex-, stage-, or tissue-specific manner. To examine sex-specific splicing, we compared gene expression profiles of male and female pupae 12 hours after pupariation. To examine stage-specific splicing, we compared expression profiles of mixed-sex, 0-24 hour old embryos and mixed-sex, 12 hour old pupae. To examine tissue-specific splicing, we compared expression profiles of adult male heads and abdomens 24-48 hours after eclosion. To examine tissue-specific splicing, we compared expression profiles of adult male heads and abdomens at 24-48 hours after eclosion. Keywords: tissue-specific expression profiles

2007-06-22 | GSE5190 | GEO

microRNA expression in human tonsillar B cell populations

Project description:small RNA profiles of 6 human tonsillar B cell populatios (naive B cells, pre-germinal center B cells, centrocytes, centroblasts, memory B cells, and plasma cells) were determined by deep sequencing. These samples were compared to mouse developing lymphocytes, various hematopoietic cell lineages, and tissues.

2010-07-24 | GSE23090 | GEO

Tissue- and stage-specific Capture-C for selected TSS and CRM

Project description:Tissue- and stage-specific Capture-C for selected TSS and CRM

| PRJEB39212 | ENA