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Dual-action host-guest chemistry suppresses PAO1 virulence in A549 cell line model

ABSTRACT: Dual-action host-guest chemistry suppresses PAO1 virulence in A549 cell line model

PROVIDER: PRJNA758054 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15622245.fastq.gz	Fastqsanger.gz
	SRR15622245_1.fastq.gz	Fastqsanger.gz
	SRR15622245_2.fastq.gz	Fastqsanger.gz
	SRR15622246.fastq.gz	Fastqsanger.gz
	SRR15622246_1.fastq.gz	Fastqsanger.gz

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Dual-action host-guest chemistry suppresses PAO1 virulence in A549 cell line model

Project description:Our study showed that selected pillararene was able to decrease the level of cell death and demage caused to human A549 epithelial cells by Pseudomonas aeruginosa PAO1 infection. To further understand the protective effects of pillararene during bacterial infections, we analyzed total mRNA isolated from the A549 epithelial cells. Our study showed that pillararene alone had minimal effect on A549 epithelial cells. The addition of PAO1 to A549 cells greatly altered expression levels. The addition of pillararene to infected A549 epithelial cells displayed a concentration-dependent reduction in the inflammatory response.

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