Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell analysis reveals fibroblast heterogeneity in chronic pancreatitis

ABSTRACT: Single-cell analysis reveals fibroblast heterogeneity in chronic pancreatitis

PROVIDER: PRJNA758564 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15661814.fastq.gz	Fastqsanger.gz

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell analysis reveals fibroblast heterogeneity in chronic pancreatitis

Project description:We used 10x Genomics Single Cell 3’v3.1 scRNA sequencing to investigate the cellular heterogeneity in chronic pancreatitis using pancreases of three CP mice. Mice were induced by daily subcutaneous re-injections of caerulein for 28 days

2022-06-22 | GSE182971 | GEO

RNA-Seq of isolated pancreatic stellate cells from mice with autoimmune pancreatitis and chronic pancreatitis

Project description:Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells(PSCs) are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted. The PSCs were isolated from animals which show autoimmune pancreatitis (NEMO knockout group) or chronic pancreatitis (NEMO wildtype group).

2023-06-30 | E-MTAB-7337 | biostudies-arrayexpress

Transcription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis

Project description:Autoimmune pancreatitis (AIP) is a recently identified disease of the pancreas with unknown etiology and antigens. The aim of this study was to determine new target antigens and differentially regulated genes and proteins by means of transcriptomics and proteomics and to validate them in patients with autoimmune pancreatitis. Here we report a distinct downregulation at the RNA and protein level of pancreatic proteases (anionic trypsinogen, cationic trypsinogen, mesotrypsinogen, elastase IIIB) and pancreatic stone protein in autoimmune pancreatitis in comparison to alcohol-induced chronic pancreatitis.

2008-12-31 | E-MEXP-804 | biostudies-arrayexpress

MicroRNA expression in Alcoholic Chronic Pancreatitis

Project description:MicroRNA expression in Alcoholic Chronic Pancreatitis

| PRJNA527719 | ENA

MicroRNA expression in Alcoholic Chronic Pancreatitis

Project description:Microarray was used to find out the differentially expressed miRNAs in Alcoholic Chronic Pancreatitis as compared to healthy control. Resulting miRNAs could be further used to understand the disease as well as could act as secretory biomarker.

2020-12-22 | GSE128425 | GEO

Chronic pancreatitis vs pancreatic cancer LC-MS

Project description:Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By radiology the evaluation of a pancreatic mass, i.e. the differential diagnosis between CP and PC is often difficult. Preoperative needle biopsies are difficult to obtain and are demanding to interpret. New blood based biomarkers are needed. The accuracy of the only established biomarker for PC, CA 19-9 is rather poor in differentiating between benign and malignant mass of the pancreas. In this study, we have performed mass spectrometry HDMSE analysis of serum samples from patients with chronic pancreatitis and pancreatic cancer. We have quantified 652 proteins and performed detailed statistical analysis such as principal component analysis, orthogonal partial least square discriminant analysis and receiver operating curve analysis.

2017-06-09 | PXD005144 | Pride

Asymmetric dimethylarginine proteome in chronic pancreatitis

Project description:The roles of protein arginine methylation in the pathongenesis of chronic pancreatitis still remains poorly understood. In this study, we performed a proteomic identification of ADMA (asymmetric dimethylarginine)-containing proteins in clinical tissues collected from chronic pancreatitis patients using affinity purification combined with LC-MS/MS.

2021-05-20 | PXD026106 |

Pancreatic gene expression associated with cerulein induced chronic pancreatitis in mice

Project description:A frequently used experimental model of chronic pancreatitis (PC) recapitulating human disease is repeated injection of cerulein to mice. We found that two common substrains of C57BL/6 , C56BL/6J (Jackson) and C57BL/6NHsd (Harlan), exhibit different degree of CP with C57BL/6J beeing more susceptible to repetitive cerulein induced CP. The goal of this study was to identify genes associated with CP and also to identify genes differentially regulated between two substrains as candidates for the CP progression. RNAs were isolated from the pancreas of 8-week old Jackson and Harlan mice after the cerulein induction of chronic pancreatitis and hybridized on Affymetrix microarrays. Saline injected mice were used as controls. Three mice from each experimental and control groups were used in the experiment.

2012-10-10 | E-GEOD-41418 | biostudies-arrayexpress

Sphingolipids Control Dermal Fibroblast Heterogeneity

Project description:Sphingolipids Control Dermal Fibroblast Heterogeneity

| PRJNA703935 | ENA

Physical Exercise-induced Extracellular Vesicles Ameliorate Chronic Pancreatitis via Inhibiting STING-Interferon Signaling

Project description:Physical Exercise-induced Extracellular Vesicles Ameliorate Chronic Pancreatitis via Inhibiting STING-Interferon Signaling

2023-08-28 | GSE241626 | GEO