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ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient

ABSTRACT: ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient

PROVIDER: PRJNA760957 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15725461_1.fastq.gz	Fastqsanger.gz
	SRR15725461_2.fastq.gz	Fastqsanger.gz
	SRR15725462_1.fastq.gz	Fastqsanger.gz
	SRR15725462_2.fastq.gz	Fastqsanger.gz
	SRR15725463_1.fastq.gz	Fastqsanger.gz

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ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient

Project description:MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. We showed that MV130 induces long term heterologous protection against viral respiratory infections in mice by a mechanism associated with the induction of trained immunity. Moreover, we found that MV130 induces reprogramming of in vitro human monocytes promoting metabolic changes and enhanced cytokine production. To assess the role of epigenetic changes in MV130-mediated trained immunity induction in human monocytes we measured the chromatin accessibility landscape using ATAC-seq.

2021-11-10 | GSE183485 | GEO

ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

Project description:ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

| PRJNA760958 | ENA

Transcriptome and chromosome accessibilty profile of HPMCs treated with high glucose containing culture medium [ATAC-Seq]

Project description:Transcriptome and chromosome accessibilty profile of HPMCs treated with high glucose containing culture medium [ATAC-Seq]

| PRJNA934470 | ENA

ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

Project description:MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. We showed that MV130 induces long term heterologous protection against viral respiratory infections in mice. Moreover, intranasal administration of MV130 provided protection against systemic candidiasis in wild-type and Rag1-deficient mice lacking functional lymphocytes, indicative of innate immune-mediated protection. As trained immunity acts via modulation of hematopoietic stem and progenitor cells (Kaufmann et al., 2018; Mitroulis et al., 2018) we hypothesized that MV130 could confer systemic long-term protection through reprogramming of hematopoietic precursors. For that we measured the chromatin accessibility landscape in multipotent progenitors (MPPs) coming from mice treated with MV130 or its excipient using ATAC-seq.

2021-11-10 | GSE183486 | GEO

ATAC-seq of human monocytes and human monocyte-derived cells.

Project description:ATAC-seq was performed to map changes in chromatin accessibility in monocytes during in vitro differentiation. In addition to control cells, we also studied the impact of siRNA mediated knock-down of key transcription factors on accessible chromatin in monocyte-derived dendritic cells.

2021-02-03 | E-MTAB-9926 | biostudies-arrayexpress

ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

Project description:ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

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Transcriptome and chromosome accessibilty profile of HPMCs treated with high glucose containing culture medium [ATAC-Seq]

Project description:RNA-seq and ATAC-seq were performed on HPMCs treated with high glucose containing culture medium

2024-10-01 | GSE225120 | GEO

ATAC-seq in human CD4+T cells, CD8+T cells, CD19+B cells and CD14+ monocytes

Project description:To test the chromatin accessibility of different immune cell subsets, we isolated CD4+T cells, CD8+T cells, CD19+B cells and CD14+ monocytes from human PBMCs and performed ATAC assay.

2020-11-05 | E-MTAB-8982 | biostudies-arrayexpress

ATAC-seq analysis to examine global accessibilty of chromatin in limb bud cells

Project description:ATAC-seq analysis to examine global accessibilty of chromatin in limb bud cells

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ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

Project description:We have identified MORC3 as a negative regulator of Type I Interferon (IFN), whose absence induces IFN and interferon-stimulated genes (ISGs). To study the global effects of MORC3 on DNA accessibility, we deleted MORC3 in IFNAR1-/- IFNAR2-/- BLaER1 monocytes and performed ATAC-seq.

2021-11-01 | GSE182752 | GEO

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