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ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

ABSTRACT: ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

PROVIDER: PRJNA760958 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15725467_1.fastq.gz	Fastqsanger.gz
	SRR15725467_2.fastq.gz	Fastqsanger.gz
	SRR15725468_1.fastq.gz	Fastqsanger.gz
	SRR15725468_2.fastq.gz	Fastqsanger.gz
	SRR15725469_1.fastq.gz	Fastqsanger.gz

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ATAC-Seq based chromatin accessibilty profile of MPPs from mice treated with MV130 or its excipient

Project description:MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. We showed that MV130 induces long term heterologous protection against viral respiratory infections in mice. Moreover, intranasal administration of MV130 provided protection against systemic candidiasis in wild-type and Rag1-deficient mice lacking functional lymphocytes, indicative of innate immune-mediated protection. As trained immunity acts via modulation of hematopoietic stem and progenitor cells (Kaufmann et al., 2018; Mitroulis et al., 2018) we hypothesized that MV130 could confer systemic long-term protection through reprogramming of hematopoietic precursors. For that we measured the chromatin accessibility landscape in multipotent progenitors (MPPs) coming from mice treated with MV130 or its excipient using ATAC-seq.

2021-11-10 | GSE183486 | GEO

ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient

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ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient

Project description:MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. We showed that MV130 induces long term heterologous protection against viral respiratory infections in mice by a mechanism associated with the induction of trained immunity. Moreover, we found that MV130 induces reprogramming of in vitro human monocytes promoting metabolic changes and enhanced cytokine production. To assess the role of epigenetic changes in MV130-mediated trained immunity induction in human monocytes we measured the chromatin accessibility landscape using ATAC-seq.

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