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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Increasing Representation of Black Communities in SARS-CoV-2 Serosurveys by Understanding Barriers and Motivations for Participation (Represent ATL)

ABSTRACT: Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Increasing Representation of Black Communities in SARS-CoV-2 Serosurveys by Understanding Barriers and Motivations for Participation (Represent ATL)

PROVIDER: PRJNA762385 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Increasing Representation of Black Communities in SARS-CoV-2 Serosurveys by Understanding Barriers and Motivations for Participation (Represent ATL)

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Increasing Representation of Black Communities in SARS-CoV-2 Serosurveys by Understanding Barriers and Motivations for Participation (Represent ATL)

| PRJNA762386 | ENA

Gene expression profiling of ATL patients

Project description:Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive and fatal disease. We have examined 18 ATL patient samples using Affymetrix HG-U133A2.0 arrays. Using the BRB array program, we identified genes differentially expressed in leukemia cells compared to normal lymphocytes. Several unique genes were identified that were overexpressed in leukemia cells including TNFSF11, RGS13, MAFb, CSPG2, C/EBPalpha and TCF4. 200 of the most highly overexpressed ATL genes were analyzed by the PathwayStudio 4.0 program. ATL leukemia cells were characterized by an increase in genes linked to "central" genes CDC2/cyclin B1, SYK/LYN, PCNA and BIRC5. Because of its potential therapeutic importance, we focused our studies on the regulation and function of BIRC5, whose expression was increased in 13 of 14 leukemia samples. TCF4 reporter assays and transfection of DN-TCF4 demonstrated that TCF4 regulates BIRC5 gene expression. Functionally, transfection of ATL cells wi BIRC5 shRNA decreased BIRC5 exprression and cell viability 80%. Clinical treatment of ATL patients with Zenapax or bortezomib decreased BIRC5 expression and cell viability. These experiments represent the first direct experimental evidence that BIRC5 plays an important role in ATL cell viability and provides important insight into ATL genesis and potential targeted therapies. Keywords: disease state analysis

2009-02-01 | GSE14317 | GEO

Transcription profiling of human adult T-cell leukemia/lymphoma (ATL) patients

2009-02-08 | E-GEOD-14317 | biostudies-arrayexpress

SNP array data for adult T-cell leukemia (ATL)

Project description:To identify chromosomal alterations in ATL, SNP array analyses were performed in 19 leukemia cell samples from ATL patients and 9 ATL-related cell lines. ATL displayed complex chromosomal abnormalities, but it contained recurrent chromosomal amplification and deletion, including 14q11 and 14q32, which may be associated with the development of ATL. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved peripheral blood samples and from cell line samples.

2017-06-06 | GSE99667 | GEO

Expression profiles of ATL patients

Project description:CD4-positive cells purified from peripheral blood of ATL patients. Keywords: other

2006-06-14 | GSE1466 | GEO

Molecular targets of proteasome inhibitor, bortezomib, on ATL cells

Project description:Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression profiling. Keywords: dose response

2007-10-09 | GSE6034 | GEO

miRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells

Project description:HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted comprehensive miRNA expression profiling in 40 ATL patients and in 22 healthy volunteers.

2012-02-23 | GSE31629 | GEO

Affymetrix SNP array data for acute T-cell leukemia/lymphoma (ATL)

Project description:SNP array analysis was performed using 168 ATL specimens. To obtain genotypes and intensities for each SNP, Affymetrix 250K SNP arrays were performed for 168 ATL samples.

2012-02-23 | E-GEOD-33602 | biostudies-arrayexpress

Whole genome gene expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells

Project description:HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted comprehensive gene expression profiling in 52 ATL patients and in 21 healthy volunteers.

2012-02-23 | GSE33615 | GEO

Molecular targets of HIV integrase inhibitor, MK-2048, on ATL cells

Project description:Adult T-cell Leukemia (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes, associated with retrovirus human T-cell leukemia virus type I (HTLV-1). To elucidate the complex molecular mechanism of anti-Growth effect of the HIV integrase inhibitor, MK-2048 in ATL cells, we attempted to perform gene expression profiling.

2020-01-01 | GSE113265 | GEO

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