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RNA-seq of 3D-culture balding and non-balding dermal papilla cells

ABSTRACT: RNA-seq of 3D-culture balding and non-balding dermal papilla cells

PROVIDER: PRJNA766679 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16089879_1.fastq.gz	Fastqsanger.gz
	SRR16089879_2.fastq.gz	Fastqsanger.gz
	SRR16089880_1.fastq.gz	Fastqsanger.gz
	SRR16089880_2.fastq.gz	Fastqsanger.gz
	SRR16089881_1.fastq.gz	Fastqsanger.gz

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RNA-seq of 3D-culture balding and non-balding dermal papilla cells

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. With the aim of elucidating genes involved in AGA pathogenesis, we cultured immortalised balding human dermal papilla cells (BAB) and immortalised non-balding human dermal papilla cells (BAN) in 3-dimensional culture format, and compared gene expression using RNA-seq between BAB and BAN cells.

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RNA-seq of 2D-culture balding and non-balding dermal papilla cells

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. With the aim of elucidating genes involved in AGA pathogenesis, we cultured immortalised balding human dermal papilla cells (BAB) and immortalised non-balding human dermal papilla cells (BAN) in 2-dimensional culture format, and compared gene expression using RNA-seq between BAB and BAN cells.

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Dermal papilla signature gene expression in immortalized human dermal papilla cells from balding and non-balding scalp

Project description:Transcriptome analysis of DP signature gene expression in hTERT-immortalized balding (BAB) and non-balding (BAN) dermal papilla cells derived from frontal and occipital scalp of male patients with androgenetic alopecia Hamilton grade IV.

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Reprogramming of dermal papilla cell intact gene signature with 3D culture and Lef-1 overexpression

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RNA-seq of 2D-culture balding and non-balding dermal papilla cells

Project description:RNA-seq of 2D-culture balding and non-balding dermal papilla cells

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Transcriptome comparison of balding and non-balding dermal papilla aggregates from NHEK co-culturing

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. The keratinocytes-surrounded spheroid dermal papilla (DP) at the base of the hair follicle is essential in hair morphogenesis and cycling. With the aim of elucidating genes involved in AGA pathogenesis, we co-cultured immortalised balding and non-balding human DP cells (DPC) derived from male AGA patients with epidermal keratinocyte (NHEK) using multi-interfacial polyelectrolyte complexation (MIPC) technique, and compared gene expression using RNA-seq between isolated balding and non-balding DP aggregates.

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Transcriptome analysis reveals differences in vasculature signalling between human dermal papilla cells from balding and non-balding scalp

Project description:Transcriptome analysis of hTERT-immortalized balding (BAB) and non-balding (BAN) dermal papilla cells derived from frontal and occipital scalp of male patients with androgenetic alopecia Hamilton grade IV. Interrogation of transcriptome differences between BAB and BAN after dihydrotestosterone (DHT, active metabolite of androgen) treatment revealed significant enrichment of vasculature-related genes among down-regulated genes in BAB compared to BAN.

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Project description:Dermal papilla cells isolated from the human hair follicle are capable of inducing hair growth in recipient epithelia. However, demonstrating disparity from rodent dermal papilla, human cells lose this inductive competance immediately upon growth in culture under normal growth conditions. We grew dermal papilla cells in hanging drop cultures that are morphologically akin to intact dermal papilla, and found that by enhancing the environment for aggregation, we could restore the inductive capacity of human dermal papilla cells in culture. The underlying genes that regulate the inductive potential of dermal papilla cells is not well understood, and we sought to use global profiling to identify key genes and pathways related to inductive competance within dermal papilla cells. We used Affymetrix microarrays to profile human dermal papilla cells in both hair inducing, and non-hair inducing states. Affymetrix microarrays were used to to perform profiling of human dermal papilla cells, both as intact tissues (freshly isolated from scalp), and at several stages in subsequent two dimensional culture; cell explant outgrowths (p0), cells at passage 1 (p1), passage 3 (p3) and passage 5 (p5). RNA was isolated from cultured cells 72 hours after feeding. Cells at passage 3 were also grown in hanging drops to form dermal spheroids, that were used for RNA collection 48 hours after establishment. All experiments were performed using tissue from three biological replicates (#D5, D6, D7),

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