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Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

ABSTRACT: Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

PROVIDER: PRJNA767285 | ENA |

REPOSITORIES: ENA

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Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:This SuperSeries is composed of the SubSeries listed below. The study demonstrate that glycosyltransferase Extl1 plays critical roles in promoting CCR7-mediated DC migration by enhancing CCR7 expression and signaling via HSPG, thus contributing to immune defense against pathogens and prevention of autoimmune diseases.

2023-01-19 | GSE184978 | GEO

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [treated vs. untreated]

Project description:Purpose: mRNAs sequencing of the gene expression differences in CCR7-stimulated mDC. The goals of this study are to investigate the biological effect of glycosyltransferase Extl1 in regulating dendritic cell function.

2023-01-19 | GSE184858 | GEO

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

| PRJNA767283 | ENA

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

| PRJNA767284 | ENA

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

| PRJNA766668 | ENA

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:Purpose: mRNAs sequencing of the gene expression differences in LPS-stimulated Extl1-dificient mDC and wild-type mDC. The goals of this study are to investigate the biological effect of glycosyltransferase Extl1 in regulating dendritic cell function.

2023-01-19 | GSE184976 | GEO

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [WT vs. KO]

Project description:Purpose: mRNAs sequencing of the gene expression differences in CCR7L-stimulated Extl1-dificient mDC and wild-type mDC. The goals of this study are to investigate the biological effect of glycosyltransferase Extl1 in regulating dendritic cell function.

2023-01-19 | GSE184861 | GEO

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [treated vs. untreated]

Project description:Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [treated vs. untreated]

| PRJNA766670 | ENA

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [WT vs. KO]

Project description:Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [WT vs. KO]

| PRJNA766671 | ENA

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Project description:The goal of this study is to investigate the role of Extl1 in regulating DC migration and subsequent adaptive immunity in vivo

2023-01-19 | GSE184977 | GEO

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