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Chromosome conformation for wild type and clb5 clb6 strains arrested in meiotic prophase I

ABSTRACT: Chromosome conformation for wild type and clb5 clb6 strains arrested in meiotic prophase I

PROVIDER: PRJNA767383 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16118186_1.fastq.gz	Fastqsanger.gz
	SRR16118186_2.fastq.gz	Fastqsanger.gz
	SRR16118187_1.fastq.gz	Fastqsanger.gz
	SRR16118187_2.fastq.gz	Fastqsanger.gz

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Project description:The meiotic cohesin Rec8 is required for the stepwise segregation of chromosomes during the two rounds of meiotic division. By directly measuring chromosome compaction in living cells of the fission yeast Schizosaccharomyces pombe, we found an additional role for the meiotic cohesin in the compaction of chromosomes during meiotic prophase. In the absence of Rec8, chromosomes were decompacted relative to those of wild-type cells. Conversely, loss of the cohesin-associated protein Pds5 resulted in hyper-compaction. While this hyper-compaction requires Rec8, binding of Rec8 to chromatin was reduced in the absence of Pds5, indicating that Pds5 promotes chromosome association of Rec8. To explain these observations, we propose that meiotic prophase chromosomes are organized as chromatin loops emanating from a Rec8-containing axis; the absence of Rec8 disrupts the axis, resulting in disorganized chromosomes, whereas reduced Rec8 loading results in a longitudinally compacted axis with fewer attachment points and longer chromatin loops. Keywords: ChIP-chip analysis ChIP analysis of Rec8: In all cases, hybridization data for ChIP fraction was compared with that of SUP (supernatant) fraction. Pombe chromosome II, III array was used.

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