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Transcriptomic profies in control or NCOR1 deficient vascular smooth muscle cells

ABSTRACT: Transcriptomic profies in control or NCOR1 deficient vascular smooth muscle cells

PROVIDER: PRJNA770251 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16289072_1.fastq.gz	Fastqsanger.gz
	SRR16289072_2.fastq.gz	Fastqsanger.gz
	SRR16289073_1.fastq.gz	Fastqsanger.gz
	SRR16289073_2.fastq.gz	Fastqsanger.gz
	SRR16289074_1.fastq.gz	Fastqsanger.gz

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Transcriptomic profies in control or NCOR1 deficient vascular smooth muscle cells

Project description:NCOR1 is a trancriptional coregulator and has been demonstrated to modulate the acitivities of multiple transcription factors in many cell types. However, the function of NCOR1 in vascular smooth muscle cells (VSMCs) is unclear. We aimed to explore the effect of NCOR1 deficiency on gene expression in VSMCs and phenoypic modulation of VSMCs. Therefore, we constructed smooth-muscle specific NCOR1 knockout mice and isolated primary VSMCs for RNA-sequencing.

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Project description:Crotonylation of histones is discovered of late as one of post-translational modification that can regulate gene expression. However, the function of crotonylation on non-histone proteins in vascular smooth muscle cells (VSMC) is unclear. Here, we aim to use modification and proteomic analysis to find the cellular characteristic of crotonylated non-histone proteins and the crosstalk with ubiquitinated proteins in vascular smooth muscle cell (VSMC) phenotypic remodeling. We performed modification and proteomic analysis of VSMCs before and after stimulated with platelet-derived growth factor-BB (PDGF-BB). The crotonylated and ubiquitinated pan-antibody was used to enrich the protein and then subjected to high-throughput mass spectrometry analysis. The enrichment analysis was performed within differentially modified proteins in regards to GO terms, KEGG and protein domain.

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