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Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

ABSTRACT: Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

PROVIDER: PRJNA771402 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16339900_1.fastq.gz	Fastqsanger.gz
	SRR16339900_2.fastq.gz	Fastqsanger.gz
	SRR16339901_1.fastq.gz	Fastqsanger.gz
	SRR16339901_2.fastq.gz	Fastqsanger.gz
	SRR16339902_1.fastq.gz	Fastqsanger.gz

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Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

Project description:This SuperSeries is composed of the SubSeries listed below.

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Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases [HiChIP]

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Sexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids

Project description:Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory hormone in all mammals and synthetic derivatives of these hormones are widely prescribed as anti-inflammatory agents irrespective of gender. Surprisingly we report a marked sexually dimorphic regulation of gene expression by glucocorticoids in the rat liver. Eight distinct patterns of glucocorticoid regulated genes were identified and two revealed genes that respond to glucocorticoid treatment in both sexes in opposite directions (anti-correlated genes. We also identified gender-specific groups of genes regulated by glucocorticoids. Pathways analysis identified sex-specific glucocorticoid regulated gene expression in several canonical pathways that have been implicated in human disease in which disease susceptibility is sex-biased. For example, comparison of number of genes involved in inflammatory disorders between sexes, revealed 84 additional glucocorticoid responsive genes in the male rat. Our data suggests that glucocorticoids thorough sexually-dimorphic regulation of gene expression modulate gender specific homeostatic functions in male and female liver.

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